<general_context>
	- Current date: 2026-11-05 21:08 UTC.
</general_context>
<company_context>
	- Ticker: XERS.
	- Company: Xeris Biopharma.
</company_context>


                <data>
                    <label>Press release on Q3 financial results and raised full-year guidance</label>
                    <content>**Exhibit 99.1**
[IMAGE: picture1reviseda.jpg | Source: picture1reviseda.jpg]
**XERIS BIOPHARMA REPORTS THIRD QUARTER 2026 FINANCIAL RESULTS AND BUSINESS HIGHLIGHTS**
*Total revenue increased 44% year-over-year to $107 million*
*Recorlev net revenue increased 93% year-over-year to more than $71 million*
*Raises full-year 2026 total revenue guidance to $395 million to $405 million*
*Raises 2030 total revenue outlook to more than $1 billion, up from approximately $750 million*
*Conference call and webcast today at 8:30 a.m. ET*
**CHICAGO — November 5, 2026** – Xeris Biopharma Holdings, Inc. \(Nasdaq: XERS\), a leading endocrine and rare disease biopharmaceutical company committed to helping people realize better lives through the development and commercialization of innovative medicines, today announced its financial results and business highlights for the third quarter ended September 30, 2026.
“As a biopharmaceutical leader in endocrine and rare diseases, our strong third quarter performance puts us on a new growth curve that is accelerating our Company’s near-term outlook, and we are now on a path to reach more than $1 billion in total revenue in 2030," said John Shannon, Chairman and Chief Executive Officer of Xeris. "This new trajectory reflects growth from the full enterprise. Net product revenue in the third quarter grew more than 43% year-over-year, led by Recorlev, where our expanded commercial team moved from build to yield and delivered record referrals and new patient starts. We now see Recorlev on a path to nearly $1 billion in annual net revenue three to four years sooner than previously expected.”
Shannon continued, “We also continued to advance XP-8121 following our comprehensive program overview in September. We remain on track to initiate Cornerstone, our pivotal Phase 3 study, by year-end. Given the strong momentum across Recorlev, Gvoke, and Keveyis, we are raising our full-year total revenue guidance to $395–$405 million.”
**<u>Third Quarter 2026 Highlights</u>**
|  |  |  | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* | \*\*Three months ended           September 30,\*\* |  |  |  | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* |
|  |  |  | \*\*2026\*\* | \*\*2026\*\* | \*\*2026\*\* |  |  |  | \*\*2025\*\* | \*\*2025\*\* | \*\*2025\*\* |  |  |  | \*\*$\*\* | \*\*$\*\* | \*\*$\*\* | \*\*%\*\* | \*\*%\*\* | \*\*%\*\* |
| Product revenue \\\(in thousands\\\): | Product revenue \\\(in thousands\\\): | Product revenue \\\(in thousands\\\): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Recorlev | Recorlev | Recorlev | $ | 71,540  |  |  |  |  | $ | 36,975  |  |  |  |  | $ | 34,565  |  | 93  | 93  |  |
| Gvoke | Gvoke | Gvoke | 21,706  | 21,706  |  |  |  |  | 25,151  | 25,151  |  |  |  |  | \\\(3,445\\\) | \\\(3,445\\\) |  | \\\(14\\\) | \\\(14\\\) |  |
| Keveyis | Keveyis | Keveyis | 13,021  | 13,021  |  |  |  |  | 11,937  | 11,937  |  |  |  |  | 1,084  | 1,084  |  | 9  | 9  |  |
| Product revenue, net | Product revenue, net | Product revenue, net | 106,267  | 106,267  |  |  |  |  | 74,063  | 74,063  |  |  |  |  | 32,204  | 32,204  |  | 43  | 43  |  |
| Royalty, contract and other revenue | Royalty, contract and other revenue | Royalty, contract and other revenue | 958  | 958  |  |  |  |  | 317  | 317  |  |  |  |  | 641  | 641  |  | 202  | 202  |  |
| Total revenue | Total revenue | Total revenue | $ | 107,225  |  |  |  |  | $ | 74,380  |  |  |  |  | $ | 32,845  |  | 44  | 44  |  |
**Total revenue** for the third quarter of 2026 was $107.2 million, an increase of 44% compared to the same period last year. The increase was primarily driven by increased patient demand for Recorlev. Gvoke delivered
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stronger-than-historical back-to-school prescription demand in the third quarter, which was offset by a one-time \($4 million\) gross-to-net adjustment.
**Gross margin** improved to 88% in the third quarter of 2026, up from 85% in the same period last year. The improvement was primarily driven by a favorable product mix.
**Research and development \(R&D\) expenses** increased by $3.6 million, or 48%, in the third quarter of 2026 compared to the same period last year. The increase in R&D expenses primarily reflects spend to support XP-8121.
**Selling, general and administrative \(SG&A\) expenses** increased by $17.6 million, or 38%, in the third quarter of 2026 compared to the same period last year. This increase mainly reflects higher personnel-related expenses to support the commercial enterprise, including the Recorlev expansion.
**Net income** for the third quarter of 2026 was $11.3 million, compared to net income of $0.6 million in the same period last year.
**Adjusted EBITDA** 1 for the third quarter of 2026 was $30.8 million, an improvement of $13.3 million compared to the same period last year.
**<u>Year-to-Date Highlights \\\(As of September 30, 2026\\\)</u>**
|  |  |  | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* | \*\*Nine months ended                 September 30,\*\* |  |  |  | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* | \*\*Change\*\* |
|  |  |  | \*\*2026\*\* | \*\*2026\*\* | \*\*2026\*\* |  |  |  | \*\*2025\*\* | \*\*2025\*\* | \*\*2025\*\* |  |  |  | \*\*$\*\* | \*\*$\*\* | \*\*$\*\* | \*\*%\*\* | \*\*%\*\* | \*\*%\*\* |
| Product revenue \\\(in thousands\\\): | Product revenue \\\(in thousands\\\): | Product revenue \\\(in thousands\\\): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Recorlev | Recorlev | Recorlev | $ | 178,088  |  |  |  |  | $ | 93,949  |  |  |  |  | $ | 84,139  |  | 90  | 90  |  |
| Gvoke | Gvoke | Gvoke | 65,055  | 65,055  |  |  |  |  | 69,463  | 69,463  |  |  |  |  | \\\(4,408\\\) | \\\(4,408\\\) |  | \\\(6\\\) | \\\(6\\\) |  |
| Keveyis | Keveyis | Keveyis | 36,582  | 36,582  |  |  |  |  | 34,849  | 34,849  |  |  |  |  | 1,733  | 1,733  |  | 5  | 5  |  |
| Other product revenue | Other product revenue | Other product revenue | —  | —  |  |  |  |  | 1,312  | 1,312  |  |  |  |  | \\\(1,312\\\) | \\\(1,312\\\) |  | —  | —  |  |
| Product revenue, net | Product revenue, net | Product revenue, net | 279,725  | 279,725  |  |  |  |  | 199,573  | 199,573  |  |  |  |  | 80,152  | 80,152  |  | 40  | 40  |  |
| Royalty, contract and other revenue | Royalty, contract and other revenue | Royalty, contract and other revenue | 2,727  | 2,727  |  |  |  |  | 6,465  | 6,465  |  |  |  |  | \\\(3,739\\\) | \\\(3,739\\\) |  | \\\(58\\\) | \\\(58\\\) |  |
| Total revenue | Total revenue | Total revenue | $ | 282,452  |  |  |  |  | $ | 206,038  |  |  |  |  | $ | 76,413  |  | 37  | 37  |  |
**Total revenue** was $282.5 million for the nine months ended September 30, 2026, an increase of 37% compared to the same period last year. The increase was primarily driven by increased patient demand for Recorlev.
**Gross margin** improved to 87%, up from 84% in the same period last year. The improvement was primarily driven by favorable product mix.
**Research and development \(R&D\) expenses** increased $7.2 million or 31% for the nine months ended September 30, 2026, compared to the same period last year. The increase in R&D expenses primarily reflects spend to support XP-8121.
**Selling, general and administrative \(SG&A\) expenses** increased $43.4 million or 32% for the nine months ended September 30, 2026, compared to the same period last year. This increase mainly reflects higher personnel-related expense to support the commercial enterprise, including the Recorlev expansion.
**Net loss** for the nine months ended September 30, 2026, was $17.6 million, compared to a net loss of $10.5 million in the same period last year. The loss was due to a one-time, non-cash charge of approximately $30.8 million in the second quarter of 2026, reflecting the increase in fair value as a result of entering into the 2028 Convertible Notes exchange agreements.
**Adjusted EBITDA** 1 for the nine months ended September 30, 2026, was $65.1 million, an improvement of $30.8 million compared to the same period last year.
1 Adjusted EBITDA is a non-GAAP financial measure. See "Note Regarding Use of Non-GAAP Financial Measures" and the corresponding financial tables at the end of this press release for definitions and reconciliations of non-GAAP measures.

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**Total Shares Outstanding** were 182,700,038 at October 30, 2026.
**<u>Key Business Highlights</u>**
* • **2028 Convertible Notes Fully Retired:** On July 15, 2026, Xeris completed the retirement of all of its 8.00% Convertible Senior Notes due 2028 through a combination of cash and the issuance of shares of common stock, eliminating approximately $34 million of debt and approximately $3 million in annual interest expense. No 2028 Convertible Notes remain outstanding, and there were no charges related to the notes in the third quarter of 2026.
* • **XP-8121 Program Overview:** On September 9, 2026, Xeris hosted a program overview detailing the comprehensive clinical development program for XP-8121, its investigational once-weekly subcutaneous levothyroxine for hypothyroidism. The pivotal Phase 3 Cornerstone study is designed to demonstrate that XP-8121 is therapeutically equivalent to daily oral levothyroxine and is expected to enroll 500 adults and adolescents with well-controlled hypothyroidism at more than 50 U.S. sites, randomized 1:1 for 54 weeks. The program also includes Capstone, a pediatric study; Touchstone, a study in patients with inconsistent thyroid control despite oral therapy; and a real-world evidence program. Xeris remains on track to initiate Cornerstone by year-end 2026, with topline data expected in late 2028 and potential approval and launch in 2030. A replay and accompanying materials are available under the “Events” section of the Xeris Investor Relations website.
* • **Third U.S. Patent Granted for XP-8121:** On October 6, 2026, the United States Patent and Trademark Office \(USPTO\) granted Xeris U.S. Patent No. 12,751,937, entitled “Stable Levothyroxine Compositions In Aprotic Polar Solvents,” which is expected to expire on October 19, 2043. This is the third U.S. patent issued for XP-8121, the Company’s investigational drug product candidate for hypothyroidism.
* • **New Patent Issued Covering Keveyis:** On October 13, 2026, the USPTO issued U.S. Patent No. 12,758,502 from U.S. Patent Application No. 17/151,405, entitled “Compositions and Methods of Use.” The claims cover the use of the Company’s KEVEYIS® \(dichlorphenamide\) product, and the patent is expected to provide intellectual property protection for Keveyis through at least 2043.
* • **Scientific Presentations:** Xeris presented real-world data at the 2026 Breakthrough T1D Clinical & Research Congress on October 9, examining healthcare provider awareness of American Diabetes Association guidelines for prescribing ready-to-use glucagon versus actual prescribing practices. The presentation, titled “Ensuring Readiness: A Case For Proactive Glucagon Prescribing For Patients At Increased Risk of Severe Hypoglycemia,” highlighted the unmet clinical need and opportunity to increase adoption of ready-to-use glucagon products. At the 21st Annual Cardiometabolic Health Congress on October 15–16, Xeris presented a case study titled “Discontinuation of Antihypertensives and Insulin in a Patient with Difficult-to-Control Type 2 Diabetes and Hypertension After Treatment With Levoketoconazole,” demonstrating cortisol normalization accompanied by improvements in multiple cardiometabolic parameters.
* • **Menassie M. Taddese appointed to the Xeris Biopharma Board of Directors:** Mr. Taddese joined the Xeris Board of Directors as an independent director, effective November 2, 2026. Mr. Taddese is an accomplished biopharmaceutical executive with nearly 30 years of global biopharmaceutical leadership experience, with a track record spanning commercial operations, corporate finance, business transformation and corporate governance.
**<u>Upcoming Events</u>**
* • **American Thyroid Association 95th Annual Meeting:** Xeris will present, for the first time publicly, a TriNetX real-world evidence analysis at the ATA Annual Meeting, being held November 4–7, 2026, in Philadelphia, PA. The retrospective analysis evaluates the feasibility of identifying and longitudinally assessing a large population of patients treated with oral levothyroxine using linked treatment records and TSH laboratory data, establishing a foundation for future real-world evidence research. At the meeting, Xeris will also unveil details of its investigator-initiated research grant program for hypothyroidism.
* • **Jefferies London Healthcare Conference:** Senior management will participate in 1x1 meetings and a fireside chat from November 16-19, 2026, in London. The fireside chat on Tuesday, November 17, will
1 Adjusted EBITDA is a non-GAAP financial measure. See "Note Regarding Use of Non-GAAP Financial Measures" and the corresponding financial tables at the end of this press release for definitions and reconciliations of non-GAAP measures.    3
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be webcast live with access available via the " [COLOR: #0e32e1]<u>Events</u>[/COLOR] " section of Xeris' Investor Relations website. Please contact the sponsor to arrange meetings with management.
* • **Piper Sandler Healthcare Conference:** Senior management will participate in 1x1 meetings and a fireside chat on December 1, 2026, in New York. The fireside chat on Tuesday, December 1, will be webcast live with access available via the " [COLOR: #0e32e1]<u>Events</u>[/COLOR] " section of Xeris' Investor Relations website. Please contact the sponsor to arrange meetings with management.
**<u>Conference Call and Webcast Details</u>**
Xeris will host a conference call and webcast at 8:30 a.m. Eastern Time today to discuss the Company's financial and operational results. Interested parties may pre-register for the call by following
[COLOR: #0e32e1]<u>https://events.q4inc.com/attendee/168342968</u>[/COLOR] . Attendees can also join via the “Events” section of the Xeris Investor Relations website.
The webcast, replay, and other information related to the event can be accessed on the investor website
[COLOR: #0e32e1]<u>https://xerispharma.com/investor-relations</u>[/COLOR] .
**<u>Note Regarding Use of Non-GAAP Financial Measures</u>**
This press release includes financial results prepared in accordance with generally accepted accounting principles in the United States \(GAAP\) and also certain historical non-GAAP financial measures, namely Adjusted EBITDA. This non-GAAP financial measure is not meant to be considered in isolation and should be read in conjunction with the Company's consolidated financial statements prepared in accordance with GAAP, and was not prepared under any comprehensive set of accounting rules or principles. Non-GAAP financial measures are not an alternative for financial measures prepared in accordance with GAAP, and the calculation of the non-GAAP financial measure included herein may differ from similarly titled measures used by other companies. The Company believes that the presentation of Adjusted EBITDA, when viewed in conjunction with actual GAAP results, provides investors with a more meaningful understanding of the Company's ongoing and projected operating performance, exclusive of factors that do not directly affect what the Company considers to be its core operating performance, as well as unusual events. The Company believes this non-GAAP financial measure helps indicate underlying trends in the Company’s business and is important in comparing current results with prior period results and understanding expected operating performance. Also, management uses this non-GAAP financial measure to establish budgets and operational goals, and to manage the Company’s business and evaluate its performance. In addition, management believes that Adjusted EBITDA is important in evaluating the administrative costs of operating the Company’s business.
Adjusted EBITDA is GAAP net income \(loss\) before income tax \(benefit\) expense, less interest and other income, plus depreciation and amortization, interest expense, share-based compensation and debt refinancing fees or extinguishment losses.
**<u>About Xeris</u>**
Xeris Biopharma Holdings, Inc. \(Nasdaq: XERS\) is a leading endocrine and rare disease biopharmaceutical company committed to helping people realize better lives through the development and commercialization of innovative medicines for serious diseases with significant unmet medical need. Xeris has three commercially available products: Recorlev ® , a cortisol synthesis inhibitor for the treatment of endogenous Cushing’s syndrome; Gvoke ® , a ready-to-use liquid glucagon for the treatment of severe hypoglycemia; and Keveyis ® , a proven therapy for primary periodic paralysis. Xeris also has a pipeline of development programs led by XP-8121, a Phase 3-ready, once-weekly subcutaneous injection for the treatment of hypothyroidism, as well as multiple early-stage programs leveraging Xeris’ technology platforms, XeriSol ® and XeriJect ® , for Xeris and its partners.
Xeris Biopharma Holdings is headquartered in Chicago, IL. For more information, visit www.xerispharma.com, or follow us on [COLOR: #3051f2]<u>X</u>[/COLOR] , [COLOR: #3051f2]<u>LinkedIn</u>[/COLOR] , or [COLOR: #3051f2]<u>Instagram</u>[/COLOR] .
**<u>Forward-Looking Statements</u>**
Any statements in this press release other than statements of historical fact are forward-looking statements. Forward-looking statements include, but are not limited to, statements about future expectations, plans, opportunities, and prospects for Xeris Biopharma Holdings, Inc., including statements regarding the
1 Adjusted EBITDA is a non-GAAP financial measure. See "Note Regarding Use of Non-GAAP Financial Measures" and the corresponding financial tables at the end of this press release for definitions and reconciliations of non-GAAP measures.

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Company’s expected benefits from its commercial investments in Recorlev in the second half of 2026 and beyond; financial guidance for full-year 2026 and the Company’s 2030 outlook for total revenue and Recorlev net revenue, including the potential for revenue growth, the Company’s ability to generate net income, Recorlev’s growth potential, the ability to continue to deliver on all full-year financial targets, the term of intellectual property protection for Keveyis, including the expectation that the recently issued patent will provide intellectual property protection for Keveyis through at least 2043, and the expected term of the Company’s issued patents covering XP-8121; the Company’s intention to protect and strengthen the long-term value of its assets; the effectiveness of the Company’s strategic execution, the Company’s ability to continue on its current growth trajectory and continue to drive patient demand, advancing its strategic initiatives, its ability to create sustainable long-term value for shareholders, the ability to continue to demonstrate sustained momentum across the portfolio and the market and therapeutic and commercial potential of its products and product candidates, including its expectations regarding the timely execution of XP-8121's ongoing development leading into the start of its Phase 3 clinical trial and the expected timing of initiation of the XP-8121 Phase 3 Cornerstone clinical trial by year-end 2026, the expected timing of topline data and potential regulatory approval and launch of XP-8121, and the Company’s comprehensive clinical development plan and commercial opportunity for XP-8121, the potential utility of its formulation platforms, the advancement of its pipeline, and other statements containing the words "achieve," "anticipate," “will,” “would,” “continue,” “expect,” “should,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These forward-looking statements are based on numerous assumptions and assessments made in light of Xeris’ experience and perception of historical trends, current conditions, business strategies, operating environment, future developments, geopolitical factors and other factors it believes appropriate. By their nature, forward-looking statements involve known and unknown risks and uncertainties because they relate to events and depend on circumstances that will occur in the future. The various factors that could cause Xeris’ actual results \(including revenue and sales in the near- and long-term\), performance or achievements, industry results, market opportunity and developments to differ materially from those expressed in or implied by such forward-looking statements \(including its 2026 guidance and 2030 outlook\), include, but are not limited to, its financial position and need for financing, including to fund its product development programs or commercialization efforts, whether its products will achieve and maintain market acceptance in a competitive business environment, its reliance on third-party suppliers, including single-source suppliers, its reliance on third parties to conduct clinical trials, the ability of its product candidates to compete successfully with existing and new drugs, its and collaborators’ ability to protect its intellectual property and proprietary technology, the accuracy and completeness of its assumptions and its ability to accurately estimate future financial results and market opportunities, and general macroeconomic and geopolitical conditions, including the possibility of an economic downturn, political unrest, trade disputes, changes in U.S. governmental priorities and resources, announced or implemented tariffs or export controls and market volatility. No assurance can be given that such expectations will be realized and persons reading this communication are, therefore, cautioned not to place undue reliance on these forward-looking statements. Additional risks and information about potential impacts of financial, operational, economic, competitive, regulatory, governmental, technological, and other factors that may affect Xeris can be found in Xeris’ filings, including its most recently filed Annual Report on Form 10-K and subsequent filings with the U.S. Securities and Exchange Commission, the contents of which are not incorporated by reference into, nor do they form part of, this communication. The risks described herein and in Xeris’ U.S. Securities and Exchange Commission filings are not the only risks the Company faces. Additional risks and uncertainties not currently known to it or that it currently deems immaterial may also impact its business operations or financial results. Forward-looking statements in this communication are based on information available to management, as of the date of this communication and, while the Company believes its assumptions are reasonable, actual results may differ materially. Subject to any obligations under applicable law, the Company does not undertake any obligation to update any forward-looking statement whether as a result of new information, future developments or otherwise, or to conform any forward-looking statement to actual results, future events, or to changes in expectations.
**<u>Investor and Media Contact</u>**
Cristi Barnett
Vice President, Investor Relations
ir@xerispharma.com
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**XERIS BIOPHARMA HOLDINGS, INC.**
**CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS**
\(in thousands, except share and per share data, unaudited\)
|  |  |  | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* |  |  |  | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  |  | \*\*2026\*\* | \*\*2026\*\* | \*\*2026\*\* |  |  |  | \*\*2025\*\* | \*\*2025\*\* | \*\*2025\*\* |  |  |  | \*\*2026\*\* | \*\*2026\*\* | \*\*2026\*\* |  |  |  | \*\*2025\*\* | \*\*2025\*\* | \*\*2025\*\* |  |  |  |  |  |  |  |  |  |  |  |  |
| Product revenue, net | Product revenue, net | Product revenue, net | $ | 106,267  |  |  |  |  | $ | 74,063  |  |  |  |  | $ | 279,725  |  |  |  |  | $ | 199,573  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Royalty, contract and other revenue | Royalty, contract and other revenue | Royalty, contract and other revenue | 958  | 958  |  |  |  |  | 317  | 317  |  |  |  |  | 2,727  | 2,727  |  |  |  |  | 6,465  | 6,465  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Total revenue | Total revenue | Total revenue | 107,225  | 107,225  |  |  |  |  | 74,380  | 74,380  |  |  |  |  | 282,452  | 282,452  |  |  |  |  | 206,038  | 206,038  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Costs and expenses: | Costs and expenses: | Costs and expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Cost of goods sold | Cost of goods sold | Cost of goods sold | 12,429  | 12,429  |  |  |  |  | 10,996  | 10,996  |  |  |  |  | 35,515  | 35,515  |  |  |  |  | 31,622  | 31,622  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|    Research and development |    Research and development |    Research and development | 11,058  | 11,058  |  |  |  |  | 7,483  | 7,483  |  |  |  |  | 30,510  | 30,510  |  |  |  |  | 23,291  | 23,291  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|    Selling, general and administrative |    Selling, general and administrative |    Selling, general and administrative | 64,108  | 64,108  |  |  |  |  | 46,459  | 46,459  |  |  |  |  | 178,287  | 178,287  |  |  |  |  | 134,870  | 134,870  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|    Amortization of intangible assets  |    Amortization of intangible assets  |    Amortization of intangible assets  | 2,711  | 2,711  |  |  |  |  | 2,711  | 2,711  |  |  |  |  | 8,132  | 8,132  |  |  |  |  | 8,132  | 8,132  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|       Total costs and expenses |       Total costs and expenses |       Total costs and expenses | 90,306  | 90,306  |  |  |  |  | 67,649  | 67,649  |  |  |  |  | 252,444  | 252,444  |  |  |  |  | 197,915  | 197,915  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Income from operations    | Income from operations    | Income from operations    | 16,919  | 16,919  |  |  |  |  | 6,731  | 6,731  |  |  |  |  | 30,008  | 30,008  |  |  |  |  | 8,123  | 8,123  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Other expenses | Other expenses | Other expenses | \\\(5,629\\\) | \\\(5,629\\\) |  |  |  |  | \\\(6,110\\\) | \\\(6,110\\\) |  |  |  |  | \\\(47,585\\\) | \\\(47,585\\\) |  |  |  |  | \\\(18,650\\\) | \\\(18,650\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Net income \\\(loss\\\) before benefit from income taxes | Net income \\\(loss\\\) before benefit from income taxes | Net income \\\(loss\\\) before benefit from income taxes | 11,290  | 11,290  |  |  |  |  | 621  | 621  |  |  |  |  | \\\(17,577\\\) | \\\(17,577\\\) |  |  |  |  | \\\(10,527\\\) | \\\(10,527\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Income tax benefit \\\(expense\\\) | Income tax benefit \\\(expense\\\) | Income tax benefit \\\(expense\\\) | —  | —  |  |  |  |  | —  | —  |  |  |  |  | —  | —  |  |  |  |  | —  | —  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|       Net income \\\(loss\\\) |       Net income \\\(loss\\\) |       Net income \\\(loss\\\) | $ | 11,290  |  |  |  |  | $ | 621  |  |  |  |  | $ | \\\(17,577\\\) |  |  |  |  | $ | \\\(10,527\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Other comprehensive income \\\(loss\\\), net of tax: | Other comprehensive income \\\(loss\\\), net of tax: | Other comprehensive income \\\(loss\\\), net of tax: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Foreign currency translation adjustments | Foreign currency translation adjustments | Foreign currency translation adjustments | \\\(1\\\) | \\\(1\\\) |  |  |  |  | \\\(1\\\) | \\\(1\\\) |  |  |  |  | 14  | 14  |  |  |  |  | —  | —  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Comprehensive income \\\(loss\\\) | Comprehensive income \\\(loss\\\) | Comprehensive income \\\(loss\\\) | $ | 11,289  |  |  |  |  | $ | 620  |  |  |  |  | $ | \\\(17,563\\\) |  |  |  |  | $ | \\\(10,527\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Net income \\\(loss\\\) per common share - basic | Net income \\\(loss\\\) per common share - basic | Net income \\\(loss\\\) per common share - basic | $ | 0.06  |  |  |  |  | $ | 0.00  |  |  |  |  | $ | \\\(0.10\\\) |  |  |  |  | $ | \\\(0.07\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Net income \\\(loss\\\) per common share - diluted | Net income \\\(loss\\\) per common share - diluted | Net income \\\(loss\\\) per common share - diluted | $ | 0.06  |  |  |  |  | $ | 0.00  |  |  |  |  | $ | \\\(0.10\\\) |  |  |  |  | $ | \\\(0.07\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Weighted average common shares outstanding: | Weighted average common shares outstanding: | Weighted average common shares outstanding: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Basic | Basic | Basic | 180,941,748  | 180,941,748  |  |  |  |  | 163,649,932  | 163,649,932  |  |  |  |  | 174,800,967  | 174,800,967  |  |  |  |  | 158,559,467  | 158,559,467  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Diluted | Diluted | Diluted | 189,924,032  | 189,924,032  |  |  |  |  | 177,617,307  | 177,617,307  |  |  |  |  | 174,800,967  | 174,800,967  |  |  |  |  | 158,559,467  | 158,559,467  |  |  |  |  |  |  |  |  |  |  |  |  |  |
5
---
**XERIS BIOPHARMA HOLDINGS, INC.**
**Non-GAAP Financial Measures - EBITDA and Adjusted EBITDA**
\(in thousands, unaudited\)
|  |  |  | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* | \*\*Three Months Ended September 30,\*\* |  |  |  | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* | \*\*Nine Months Ended September 30,\*\* |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  |  | \*\*2026\*\* | \*\*2026\*\* | \*\*2026\*\* |  |  |  | \*\*2025\*\* | \*\*2025\*\* | \*\*2025\*\* |  |  |  | \*\*2026\*\* | \*\*2026\*\* | \*\*2026\*\* |  |  |  | \*\*2025\*\* | \*\*2025\*\* | \*\*2025\*\* |  |  |  |  |  |  |  |  |  |  |  |  |
| GAAP Net income \\\(loss\\\) | GAAP Net income \\\(loss\\\) | GAAP Net income \\\(loss\\\) | $ | 11,290  |  |  |  |  | $ | 621  |  |  |  |  | $ | \\\(17,577\\\) |  |  |  |  | $ | \\\(10,527\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Adjustments | Adjustments | Adjustments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Interest and other income | Interest and other income | Interest and other income | \\\(827\\\) | \\\(827\\\) |  |  |  |  | \\\(1,158\\\) | \\\(1,158\\\) |  |  |  |  | \\\(3,484\\\) | \\\(3,484\\\) |  |  |  |  | \\\(3,281\\\) | \\\(3,281\\\) |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Interest expense | Interest expense | Interest expense | 6,456  | 6,456  |  |  |  |  | 7,268  | 7,268  |  |  |  |  | 20,287  | 20,287  |  |  |  |  | 21,931  | 21,931  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Depreciation and amortization | Depreciation and amortization | Depreciation and amortization | 3,029  | 3,029  |  |  |  |  | 3,049  | 3,049  |  |  |  |  | 9,110  | 9,110  |  |  |  |  | 9,110  | 9,110  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| EBITDA | EBITDA | EBITDA | $ | 19,948  |  |  |  |  | $ | 9,780  |  |  |  |  | $ | 8,336  |  |  |  |  | $ | 17,233  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Adjustments | Adjustments | Adjustments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Share-based compensation \\\(a\\\) | Share-based compensation \\\(a\\\) | Share-based compensation \\\(a\\\) | 10,802  | 10,802  |  |  |  |  | 7,643  | 7,643  |  |  |  |  | 26,008  | 26,008  |  |  |  |  | 17,094  | 17,094  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Loss on debt extinguishment, net | Loss on debt extinguishment, net | Loss on debt extinguishment, net | —  | —  |  |  |  |  | —  | —  |  |  |  |  | 30,782  | 30,782  |  |  |  |  | —  | —  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Adjusted EBITDA | Adjusted EBITDA | Adjusted EBITDA | $ | 30,750  |  |  |  |  | $ | 17,423  |  |  |  |  | $ | 65,126  |  |  |  |  | $ | 34,327  |  |  |  |  |  |  |  |  |  |  |  |  |  |
1. \(a\) Includes non-cash, stock-based compensation, net of forfeitures.
6
---
**XERIS BIOPHARMA HOLDINGS, INC.**
**CONDENSED CONSOLIDATED BALANCE SHEETS**
\(in thousands\)
|  |  |  | \*\*September 30, 2026\*\* | \*\*September 30, 2026\*\* | \*\*September 30, 2026\*\* |  |  |  | \*\*December 31, 2025\*\* | \*\*December 31, 2025\*\* | \*\*December 31, 2025\*\* |
| \*\*Assets\*\* | \*\*Assets\*\* | \*\*Assets\*\* | \\\(unaudited\\\) | \\\(unaudited\\\) | \\\(unaudited\\\) |  |  |  |  |  |  |
| Current assets: | Current assets: | Current assets: |  |  |  |  |  |  |  |  |  |
| Cash and cash equivalents | Cash and cash equivalents | Cash and cash equivalents | $ | 131,082 | 131,082 |  |  |  | $ | 111,042 | 111,042 |
| Trade accounts receivable, net | Trade accounts receivable, net | Trade accounts receivable, net | 68,596 | 68,596 | 68,596 |  |  |  | 51,050 | 51,050 | 51,050 |
| Inventory, net | Inventory, net | Inventory, net | 76,925 | 76,925 | 76,925 |  |  |  | 68,673 | 68,673 | 68,673 |
| Prepaid expenses and other current assets | Prepaid expenses and other current assets | Prepaid expenses and other current assets | 12,662 | 12,662 | 12,662 |  |  |  | 9,548 | 9,548 | 9,548 |
| Total current assets | Total current assets | Total current assets | 289,265 | 289,265 | 289,265 |  |  |  | 240,313 | 240,313 | 240,313 |
| Property and equipment, net | Property and equipment, net | Property and equipment, net | 4,638 | 4,638 | 4,638 |  |  |  | 4,945 | 4,945 | 4,945 |
| Operating lease right-of-use assets | Operating lease right-of-use assets | Operating lease right-of-use assets | 21,584 | 21,584 | 21,584 |  |  |  | 22,112 | 22,112 | 22,112 |
| Goodwill | Goodwill | Goodwill | 22,859 | 22,859 | 22,859 |  |  |  | 22,859 | 22,859 | 22,859 |
| Intangible assets, net | Intangible assets, net | Intangible assets, net | 79,946 | 79,946 | 79,946 |  |  |  | 88,078 | 88,078 | 88,078 |
| Other assets | Other assets | Other assets | 4,927 | 4,927 | 4,927 |  |  |  | 5,220 | 5,220 | 5,220 |
| Total assets | Total assets | Total assets | $ | 423,219 | 423,219 |  |  |  | $ | 383,527 | 383,527 |
| \*\*Liabilities and Stockholders’ Equity\*\* | \*\*Liabilities and Stockholders’ Equity\*\* | \*\*Liabilities and Stockholders’ Equity\*\* |  |  |  |  |  |  |  |  |  |
| Current liabilities: | Current liabilities: | Current liabilities: |  |  |  |  |  |  |  |  |  |
| Accounts payable | Accounts payable | Accounts payable | $ | 8,040 | 8,040 |  |  |  | $ | 3,076 | 3,076 |
| Current operating lease liabilities | Current operating lease liabilities | Current operating lease liabilities | 6,349 | 6,349 | 6,349 |  |  |  | 6,232 | 6,232 | 6,232 |
| Other accrued liabilities | Other accrued liabilities | Other accrued liabilities | 47,366 | 47,366 | 47,366 |  |  |  | 33,155 | 33,155 | 33,155 |
| Accrued trade discounts and rebates | Accrued trade discounts and rebates | Accrued trade discounts and rebates | 51,028 | 51,028 | 51,028 |  |  |  | 43,253 | 43,253 | 43,253 |
| Accrued returns reserve | Accrued returns reserve | Accrued returns reserve | 17,674 | 17,674 | 17,674 |  |  |  | 18,969 | 18,969 | 18,969 |
| Other current liabilities | Other current liabilities | Other current liabilities | 4,022 | 4,022 | 4,022 |  |  |  | 4,889 | 4,889 | 4,889 |
| Total current liabilities | Total current liabilities | Total current liabilities | 134,479 | 134,479 | 134,479 |  |  |  | 109,574 | 109,574 | 109,574 |
| Long-term debt, net of unamortized debt issuance costs | Long-term debt, net of unamortized debt issuance costs | Long-term debt, net of unamortized debt issuance costs | 189,713 | 189,713 | 189,713 |  |  |  | 220,335 | 220,335 | 220,335 |
| Non-current operating lease liabilities | Non-current operating lease liabilities | Non-current operating lease liabilities | 30,004 | 30,004 | 30,004 |  |  |  | 31,531 | 31,531 | 31,531 |
| Other liabilities | Other liabilities | Other liabilities | 20,239 | 20,239 | 20,239 |  |  |  | 8,398 | 8,398 | 8,398 |
| Total liabilities | Total liabilities | Total liabilities | 374,435 | 374,435 | 374,435 |  |  |  | 369,838 | 369,838 | 369,838 |
| Total stockholders’ equity | Total stockholders’ equity | Total stockholders’ equity | 48,784 | 48,784 | 48,784 |  |  |  | 13,689 | 13,689 | 13,689 |
| Total liabilities and stockholders’ equity | Total liabilities and stockholders’ equity | Total liabilities and stockholders’ equity | $ | 423,219 | 423,219 |  |  |  | $ | 383,527 | 383,527 |
7</content>
                </data>
            

                <data>
                    <label>XERS 10-Q, date: 2026-11-05 21:08 UTC</label>
                    <content>### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### FORM 10-Q
<div align='center'>(Mark One)</div>

| ☒                                                 
 For the quarterly period endedSeptember 30, 2026  |     | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934  |
|:--------------------------------------------------|:----|:-----------------------------------------------------------------------------------------|
| or                                                |     |                                                                                          |
| ☐                                                 |     | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
| For the transition period from _______ to _______ |     |                                                                                          |
| Commission file number:001-40880                  |     |                                                                                          |

#### XERIS BIOPHARMA HOLDINGS, INC.
<div align='center'>(Exact name of registrant as specified in its charter)</div>

|                                                                                    |     | Delaware                                |     |                   |     |                                87-1082097 |
|                                                                                    |     | -State or other jurisdiction of         
 incorporation or organization           |     |                   |     |       -I.R.S. Employer Identification No. |
|                                                                                    |     | 1375 West Fulton Street,Suite 1300      
 Chicago,Illinois                        |     |                   |     |                                     60607 |
|                                                                                    |     | -Address of principal executive offices |     |                   |     |                                 -Zip Code |
| (844)445-5704                                                                      |     |                                         |     |                   |     |                                           |
| (Registrant's telephone number, including area code)                               |     |                                         |     |                   |     |                                           |
| Not applicable                                                                     |     |                                         |     |                   |     |                                           |
| (Former name, former address and former fiscal year, if changed since last report) |     |                                         |     |                   |     |                                           |
| Securities registered pursuant to Section 12(b) of the Act:                        |     |                                         |     |                   |     |                                           |
| Title of each class                                                                |     |                                         |     | Trading Symbol(s) |     | Name of each exchange on which registered |
| Common Stock, $0.0001 par value per share                                          |     |                                         |     | XERS              |     |           The Nasdaq Global Select Market |

| Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.Yes☒     No¨ |     |                          |     |                           |     |   |
| Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).Yes☒     No¨                                     |     |                          |     |                           |     |   |
| Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.          |     |                          |     |                           |     |   |
|                                                                                                                                                                                                                                                                                                                                                                      |     | Large accelerated filer☒ |     | Accelerated filer         |     | ¨ |
|                                                                                                                                                                                                                                                                                                                                                                      |     | Non-accelerated filer¨   |     | Smaller reporting company |     | ¨ |
|                                                                                                                                                                                                                                                                                                                                                                      |     |                          |     | Emerging growth company   |     | ¨ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

As of October 30, 2026, 182,700,038shares, par value $0.0001 per share, of common stock were outstanding.

#### XERIS BIOPHARMA HOLDINGS, INC.

#### Index to Quarterly Report on Form 10-Q
|                               |     |                                                                                               |     |                                                                                                                                           |     | Page |
| Part I. Financial Information |     |                                                                                               |     |                                                                                                                                           |     |      |
|                               |     | Item 1. Financial Statements                                                                  |     |                                                                                                                                           |     |      |
|                               |     |                                                                                               |     | Condensed Consolidated Balance Sheets as ofSeptember30, 2026 and December 31, 2025                                                        |     |    3 |
|                               |     |                                                                                               |     | Condensed Consolidated Statements of Operations and ComprehensiveIncome (Loss)for the three andninemonths endedSeptember30, 2026 and 2025 |     |    4 |
|                               |     |                                                                                               |     | Condensed Consolidated Statements of Stockholders'Equity(Deficit)for the three andninemonths endedSeptember30, 2026 and 2025              |     |    5 |
|                               |     |                                                                                               |     | Condensed Consolidated Statements of Cash Flowsfor theninemonths endedSeptember30, 2026 and 2025                                          |     |    7 |
|                               |     |                                                                                               |     | Notes to Condensed Consolidated Financial Statements                                                                                      |     |    9 |
|                               |     | Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations |     |                                                                                                                                           |     |   23 |
|                               |     | Item 3. Quantitative and Qualitative Disclosures About Market Risk                            |     |                                                                                                                                           |     |   30 |
|                               |     | Item 4. Controls and Procedures                                                               |     |                                                                                                                                           |     |   30 |
| Part II. Other Information    |     |                                                                                               |     |                                                                                                                                           |     |      |
|                               |     | Item 1. Legal Proceedings                                                                     |     |                                                                                                                                           |     |   31 |
|                               |     | Item 1A. Risk Factors                                                                         |     |                                                                                                                                           |     |   32 |
|                               |     | Item 2. Unregistered Sales of Equity Securities and Use of Proceeds                           |     |                                                                                                                                           |     |   32 |
|                               |     | Item 3. Defaults Upon Senior Securities                                                       |     |                                                                                                                                           |     |   32 |
|                               |     | Item 4. Mine Safety Disclosures                                                               |     |                                                                                                                                           |     |   32 |
|                               |     | Item 5. Other Information                                                                     |     |                                                                                                                                           |     |   32 |
|                               |     | Item 6. Exhibits                                                                              |     |                                                                                                                                           |     |   33 |
|                               |     | Signatures                                                                                    |     |                                                                                                                                           |     |   34 |

Solely for convenience, the trademarks and trade names in this Quarterly Report on Form 10-Q (this "Quarterly Report") are referred to without the ® and ™ symbols, but absence of such references should not be construed as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto. The trademarks, trade names and service marks appearing in this Quarterly Report are the property of their respective owners.

#### PART I. FINANCIAL INFORMATION

## ITEM 1. FINANCIAL STATEMENTS

#### XERIS BIOPHARMA HOLDINGS, INC.

#### Condensed Consolidated Balance Sheets
<div align='center'>(in thousands, except share and par value)</div>

|                                                                                                                                                                                                                                |     |   |            | September 30, 2026 |     |   |     | December 31, 2025 |
|:-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|:----|:--|:-----------|-------------------:|:----|:--|:----|------------------:|
| Assets                                                                                                                                                                                                                         |     |   | -unaudited |                    |     |   |     |                   |
| Current assets:                                                                                                                                                                                                                |     |   |            |                    |     |   |     |                   |
| Cash and cash equivalents                                                                                                                                                                                                      |     | $ |            |            131,082 |     | $ |     |           111,042 |
| Trade accounts receivable, net                                                                                                                                                                                                 |     |   |            |             68,596 |     |   |     |            51,050 |
| Inventory, net                                                                                                                                                                                                                 |     |   |            |             76,925 |     |   |     |            68,673 |
| Prepaid expenses and other current assets                                                                                                                                                                                      |     |   |            |             12,662 |     |   |     |             9,548 |
| Total current assets                                                                                                                                                                                                           |     |   |            |            289,265 |     |   |     |           240,313 |
| Property and equipment, net                                                                                                                                                                                                    |     |   |            |              4,638 |     |   |     |             4,945 |
| Operating lease right-of-use assets                                                                                                                                                                                            |     |   |            |             21,584 |     |   |     |            22,112 |
| Goodwill                                                                                                                                                                                                                       |     |   |            |             22,859 |     |   |     |            22,859 |
| Intangible assets, net                                                                                                                                                                                                         |     |   |            |             79,946 |     |   |     |            88,078 |
| Other assets                                                                                                                                                                                                                   |     |   |            |              4,927 |     |   |     |             5,220 |
| Total assets                                                                                                                                                                                                                   |     | $ |            |            423,219 |     | $ |     |           383,527 |
| Liabilities and Stockholders' Equity                                                                                                                                                                                           |     |   |            |                    |     |   |     |                   |
| Current liabilities:                                                                                                                                                                                                           |     |   |            |                    |     |   |     |                   |
| Accounts payable                                                                                                                                                                                                               |     | $ |            |              8,040 |     | $ |     |             3,076 |
| Current operating lease liabilities                                                                                                                                                                                            |     |   |            |              6,349 |     |   |     |             6,232 |
| Other accrued liabilities                                                                                                                                                                                                      |     |   |            |             47,366 |     |   |     |            33,155 |
| Accrued trade discounts and rebates                                                                                                                                                                                            |     |   |            |             51,028 |     |   |     |            43,253 |
| Accrued returns reserve                                                                                                                                                                                                        |     |   |            |             17,674 |     |   |     |            18,969 |
| Other current liabilities                                                                                                                                                                                                      |     |   |            |              4,022 |     |   |     |             4,889 |
| Total current liabilities                                                                                                                                                                                                      |     |   |            |            134,479 |     |   |     |           109,574 |
| Long-term debt, net of unamortized debt issuance costs                                                                                                                                                                         |     |   |            |            189,713 |     |   |     |           220,335 |
| Non-current operating lease liabilities                                                                                                                                                                                        |     |   |            |             30,004 |     |   |     |            31,531 |
| Other liabilities                                                                                                                                                                                                              |     |   |            |             20,239 |     |   |     |             8,398 |
| Total liabilities                                                                                                                                                                                                              |     |   |            |            374,435 |     |   |     |           369,838 |
| Commitments and contingencies (Note 13)                                                                                                                                                                                        |     |   |            |                    |     |   |     |                   |
| Stockholders' equity:                                                                                                                                                                                                          |     |   |            |                    |     |   |     |                   |
| Preferred stock—par value $0.0001,25,000,000shares authorized andnoshares issued and outstanding as of September 30, 2026 and December 31, 2025                                                                                |     |   |            |                  — |     |   |     |                 — |
| Common stock—par value $0.0001,350,000,000shares authorized as of September 30, 2026 and December 31, 2025;182,567,511and166,215,410shares issued and outstanding as of September 30, 2026 and December 31, 2025, respectively |     |   |            |                 19 |     |   |     |                17 |
| Additional paid in capital                                                                                                                                                                                                     |     |   |            |            737,660 |     |   |     |           685,004 |
| Accumulated deficit                                                                                                                                                                                                            |     |   |            |           -688,884 |     |   |     |          -671,307 |
| Accumulated other comprehensive loss                                                                                                                                                                                           |     |   |            |                -11 |     |   |     |               -25 |
| Total stockholders' equity                                                                                                                                                                                                     |     |   |            |             48,784 |     |   |     |            13,689 |
| Total liabilities and stockholders' equity                                                                                                                                                                                     |     | $ |            |            423,219 |     | $ |     |           383,527 |

See accompanying notes to condensed consolidated financial statements.

<div align='center'>3</div>

#### XERIS BIOPHARMA HOLDINGS, INC.
<div align='center'>Condensed Consolidated Statements of Operations and Comprehensive Income (Loss)

(in thousands, except share and per share data, unaudited)</div>

|                                                |     |   | Three Months Ended September 30, 
                             2026 |     |   |        2025 |     |   | Nine Months Ended September 30, 
                            2026 |     |   |        2025 |
|:-----------------------------------------------|:----|:--|---------------------------------:|:----|:--|------------:|:----|:--|--------------------------------:|:----|:--|------------:|
| Product revenue, net                           |     | $ |                          106,267 |     | $ |      74,063 |     | $ |                         279,725 |     | $ |     199,573 |
| Royalty, contract and other revenue            |     |   |                              958 |     |   |         317 |     |   |                           2,727 |     |   |       6,465 |
| Total revenue                                  |     |   |                          107,225 |     |   |      74,380 |     |   |                         282,452 |     |   |     206,038 |
| Costs and expenses:                            |     |   |                                  |     |   |             |     |   |                                 |     |   |             |
| Cost of goods sold                             |     |   |                           12,429 |     |   |      10,996 |     |   |                          35,515 |     |   |      31,622 |
| Research and development                       |     |   |                           11,058 |     |   |       7,483 |     |   |                          30,510 |     |   |      23,291 |
| Selling, general and administrative            |     |   |                           64,108 |     |   |      46,459 |     |   |                         178,287 |     |   |     134,870 |
| Amortization of intangible assets              |     |   |                            2,711 |     |   |       2,711 |     |   |                           8,132 |     |   |       8,132 |
| Total costs and expenses                       |     |   |                           90,306 |     |   |      67,649 |     |   |                         252,444 |     |   |     197,915 |
| Income from operations                         |     |   |                           16,919 |     |   |       6,731 |     |   |                          30,008 |     |   |       8,123 |
| Other income (expense):                        |     |   |                                  |     |   |             |     |   |                                 |     |   |             |
| Interest and other income                      |     |   |                              827 |     |   |       1,158 |     |   |                           3,484 |     |   |       3,281 |
| Loss on debt extinguishment, net               |     |   |                                — |     |   |           — |     |   |                         -30,782 |     |   |           — |
| Interest expense                               |     |   |                           -6,456 |     |   |      -7,268 |     |   |                         -20,287 |     |   |     -21,931 |
| Total other expense                            |     |   |                           -5,629 |     |   |      -6,110 |     |   |                         -47,585 |     |   |     -18,650 |
| Net income (loss) before income taxes          |     |   |                           11,290 |     |   |         621 |     |   |                         -17,577 |     |   |     -10,527 |
| Income tax benefit (expense)                   |     |   |                                — |     |   |           — |     |   |                               — |     |   |           — |
| Net income (loss)                              |     | $ |                           11,290 |     | $ |         621 |     | $ |                         -17,577 |     | $ |     -10,527 |
| Other comprehensive income (loss), net of tax: |     |   |                                  |     |   |             |     |   |                                 |     |   |             |
| Foreign currency translation adjustments       |     |   |                               -1 |     |   |          -1 |     |   |                              14 |     |   |           — |
| Comprehensive income (loss)                    |     | $ |                           11,289 |     | $ |         620 |     | $ |                         -17,563 |     | $ |     -10,527 |
| Net income (loss) per common share - basic     |     | $ |                             0.06 |     | $ |        0.00 |     | $ |                           -0.10 |     | $ |       -0.07 |
| Net income (loss) per common share - diluted   |     | $ |                             0.06 |     | $ |        0.00 |     | $ |                           -0.10 |     | $ |       -0.07 |
| Weighted average common shares outstanding:    |     |   |                                  |     |   |             |     |   |                                 |     |   |             |
| Basic                                          |     |   |                      180,941,748 |     |   | 163,649,932 |     |   |                     174,800,967 |     |   | 158,559,467 |
| Diluted                                        |     |   |                      189,924,032 |     |   | 177,617,307 |     |   |                     174,800,967 |     |   | 158,559,467 |

See accompanying notes to condensed consolidated financial statements.

<div align='center'>4</div>

#### XERIS BIOPHARMA HOLDINGS, INC.
<div align='center'>Condensed Consolidated Statements of Stockholders' Equity (Deficit)

(in thousands, except share data, unaudited)</div>

|                                                                            |     | Common Stock 
       Shares |     |   | Amount |     |   | Additional Paid In 
            Capital |     |   | Accumulated Other Comprehensive Loss |     |   | Accumulated Deficit |     |   |            Total 
    Stockholders' 
 Equity (Deficit) |
|:---------------------------------------------------------------------------|:----|-------------:|:----|:--|-------:|:----|:--|-------------------:|:----|:--|-------------------------------------:|:----|:--|--------------------:|:----|:--|-----------------:|
| Balance, December 31, 2024                                                 |     |  149,429,410 |     | $ |     15 |     | $ |            642,256 |     | $ |                                  -25 |     | $ |            -671,861 |     | $ |          -29,615 |
| Net loss                                                                   |     |            — |     |   |      — |     |   |                  — |     |   |                                    — |     |   |              -9,220 |     |   |           -9,220 |
| Exercise of stock options                                                  |     |    1,366,498 |     |   |      — |     |   |              4,960 |     |   |                                    — |     |   |                   — |     |   |            4,960 |
| Vesting of restricted stock units (net of2,255,124shares withheld for tax) |     |    3,721,805 |     |   |      1 |     |   |             -7,999 |     |   |                                      |     |   |                   — |     |   |           -7,998 |
| Issuance of common shares in partial settlement of 2025 Convertible Debt   |     |    1,045,752 |     |   |      — |     |   |              3,188 |     |   |                                    — |     |   |                   — |     |   |            3,188 |
| Issuance of common shares in settlement of warrants                        |     |      450,585 |     |   |      — |     |   |                  — |     |   |                                    — |     |   |                   — |     |   |                — |
| Stock-based compensation                                                   |     |            — |     |   |      — |     |   |              3,557 |     |   |                                    — |     |   |                   — |     |   |            3,557 |
| Balance, March 31, 2025                                                    |     |  156,014,050 |     | $ |     16 |     | $ |            645,962 |     | $ |                                  -25 |     | $ |            -681,081 |     | $ |          -35,128 |
| Net loss                                                                   |     |            — |     |   |      — |     |   |                  — |     |   |                                    — |     |   |              -1,928 |     |   |           -1,928 |
| Exercise of stock options                                                  |     |      315,724 |     |   |      — |     |   |              1,152 |     |   |                                    — |     |   |                   — |     |   |            1,152 |
| Vesting of restricted stock units (net of170,442shares withheld for tax)   |     |      680,154 |     |   |      — |     |   |               -859 |     |   |                                    — |     |   |                   — |     |   |             -859 |
| Issuance of common shares in settlement of 2025 Convertible Debt           |     |    3,932,399 |     |   |      — |     |   |             11,958 |     |   |                                    — |     |   |                   — |     |   |           11,958 |
| Issuance of common stock through                                           
 employee stock purchase plan                                               |     |      282,435 |     |   |      — |     |   |                830 |     |   |                                    — |     |   |                   — |     |   |              830 |
| Stock-based compensation                                                   |     |            — |     |   |      — |     |   |              4,670 |     |   |                                    — |     |   |                   — |     |   |            4,670 |
| Other comprehensive income                                                 |     |            — |     |   |      — |     |   |                  — |     |   |                                    1 |     |   |                   — |     |   |                1 |
| Balance, June 30, 2025                                                     |     |  161,224,762 |     | $ |     16 |     | $ |            663,713 |     | $ |                                  -24 |     | $ |            -683,009 |     | $ |          -19,304 |
| Net income                                                                 |     |            — |     |   |      — |     |   |                  — |     |   |                                    — |     |   |                 621 |     |   |              621 |
| Exercise of stock options                                                  |     |    1,179,760 |     |   |      — |     |   |              5,183 |     |   |                                    — |     |   |                   — |     |   |            5,183 |
| Vesting of restricted stock units (net of93,725shares withheld for tax)    |     |      167,986 |     |   |      — |     |   |               -478 |     |   |                                    — |     |   |                   — |     |   |             -478 |
| Issuance of common shares for warrants exercised                           |     |    2,955,745 |     |   |      1 |     |   |              9,166 |     |   |                                    — |     |   |                   — |     |   |            9,167 |
| Stock-based compensation                                                   |     |            — |     |   |      — |     |   |              3,951 |     |   |                                    — |     |   |                   — |     |   |            3,951 |
| Other comprehensive loss                                                   |     |            — |     |   |      — |     |   |                  — |     |   |                                   -1 |     |   |                   — |     |   |               -1 |
| Balance, September 30, 2025                                                |     |  165,528,253 |     | $ |     17 |     | $ |            681,535 |     | $ |                                  -25 |     | $ |            -682,388 |     | $ |             -861 |

<div align='center'>5</div>

#### XERIS BIOPHARMA HOLDINGS, INC.
<div align='center'>Condensed Consolidated Statements of Stockholders' Equity (Deficit)

(in thousands, except share data, unaudited)</div>

|                                                                            |     | Common Stock 
       Shares |     |   | Amount |     |   | Additional Paid In 
            Capital |     |   | Accumulated Other Comprehensive Loss |     |   | Accumulated Deficit |     |   |            Total 
    Stockholders' 
 Equity (Deficit) |
|:---------------------------------------------------------------------------|:----|-------------:|:----|:--|-------:|:----|:--|-------------------:|:----|:--|-------------------------------------:|:----|:--|--------------------:|:----|:--|-----------------:|
| Balance, December 31, 2025                                                 |     |  166,215,410 |     | $ |     17 |     | $ |            685,004 |     | $ |                                  -25 |     | $ |            -671,307 |     | $ |           13,689 |
| Net income                                                                 |     |            — |     |   |      — |     |   |                  — |     |   |                                    — |     |   |               2,234 |     |   |            2,234 |
| Exercise of stock options                                                  |     |      259,935 |     |   |      — |     |   |                847 |     |   |                                    — |     |   |                   — |     |   |              847 |
| Vesting of restricted stock units (net of2,314,943shares withheld for tax) |     |    3,808,125 |     |   |      1 |     |   |            -17,018 |     |   |                                    — |     |   |                   — |     |   |          -17,017 |
| Issuance of common shares in settlement of warrants                        |     |    2,275,313 |     |   |      — |     |   |              7,333 |     |   |                                    — |     |   |                   — |     |   |            7,333 |
| Stock-based compensation                                                   |     |            — |     |   |      — |     |   |              5,924 |     |   |                                    — |     |   |                   — |     |   |            5,924 |
| Other comprehensive income                                                 |     |            — |     |   |      — |     |   |                  — |     |   |                                    1 |     |   |                   — |     |   |                1 |
| Balance, March 31, 2026                                                    |     |  172,558,783 |     | $ |     18 |     | $ |            682,090 |     | $ |                                  -24 |     | $ |            -669,073 |     | $ |           13,011 |
| Net loss                                                                   |     |            — |     |   |      — |     |   |                  — |     |   |                                    — |     |   |             -31,101 |     |   |          -31,101 |
| Exercise of stock options                                                  |     |      248,124 |     |   |      — |     |   |                580 |     |   |                                    — |     |   |                   — |     |   |              580 |
| Vesting of restricted stock units (net of31,690shares withheld for tax)    |     |      363,980 |     |   |      — |     |   |               -191 |     |   |                                    — |     |   |                   — |     |   |             -191 |
| Issuance of common stock through employee stock purchase plan              |     |      157,592 |     |   |      — |     |   |                985 |     |   |                                    — |     |   |                   — |     |   |              985 |
| Issuance of common shares in settlement of warrants                        |     |      263,158 |     |   |      — |     |   |                600 |     |   |                                    — |     |   |                   — |     |   |              600 |
| Stock-based compensation                                                   |     |            — |     |   |      — |     |   |              6,368 |     |   |                                    — |     |   |                   — |     |   |            6,368 |
| Other comprehensive income                                                 |     |            — |     |   |      — |     |   |                  — |     |   |                                   14 |     |   |                   — |     |   |               14 |
| Balance, June 30, 2026                                                     |     |  173,591,637 |     | $ |     18 |     | $ |            690,432 |     | $ |                                  -10 |     | $ |            -700,174 |     | $ |           -9,734 |
| Net loss                                                                   |     |            — |     |   |      — |     |   |                  — |     |   |                                    — |     |   |              11,290 |     |   |           11,290 |
| Exercise of stock options                                                  |     |      231,456 |     |   |      — |     |   |                628 |     |   |                                    — |     |   |                   — |     |   |              628 |
| Vesting of restricted stock units (net of93,156shares withheld for tax)    |     |      141,245 |     |   |      — |     |   |               -752 |     |   |                                    — |     |   |                   — |     |   |             -752 |
| Issuance of common shares in partial settlement of 2028 Convertible Debt   |     |    8,595,609 |     |   |      1 |     |   |             40,708 |     |   |                                    — |     |   |                   — |     |   |           40,709 |
| Issuance of common stock through employee stock purchase plan              |     |        7,564 |     |   |      — |     |   |                 47 |     |   |                                    — |     |   |                   — |     |   |               47 |
| Stock-based compensation                                                   |     |            — |     |   |      — |     |   |              6,597 |     |   |                                    — |     |   |                   — |     |   |            6,597 |
| Other comprehensive income                                                 |     |            — |     |   |      — |     |   |                  — |     |   |                                   -1 |     |   |                   — |     |   |               -1 |
| Balance, September 30, 2026                                                |     |  182,567,511 |     | $ |     19 |     | $ |            737,660 |     | $ |                                  -11 |     | $ |            -688,884 |     | $ |           48,784 |

See accompanying notes to condensed consolidated financial statements.

<div align='center'>6</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

#### Condensed Consolidated Statements of Cash Flows
<div align='center'>(in thousands, unaudited)</div>

| Cash flows from operating activities:                                                     |     | Nine Months Ended September 30, |     |   |    2026 |     |   |    2025 |
|:------------------------------------------------------------------------------------------|:----|:--------------------------------|:----|:--|--------:|:----|:--|--------:|
| Net loss                                                                                  |     |                                 |     | $ | -17,577 |     | $ | -10,527 |
| Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |     |                                 |     |   |         |     |   |         |
| Depreciation                                                                              |     |                                 |     |   |     978 |     |   |     978 |
| Amortization of intangible assets                                                         |     |                                 |     |   |   8,132 |     |   |   8,132 |
| Amortization of debt discount and debt issuance costs                                     |     |                                 |     |   |   2,702 |     |   |   2,507 |
| Amortization of operating right-of-use assets                                             |     |                                 |     |   |     528 |     |   |     386 |
| Stock-based compensation                                                                  |     |                                 |     |   |  26,008 |     |   |  17,094 |
| Loss on extinguishment of debt                                                            |     |                                 |     |   |  30,782 |     |   |       — |
| Changes in operating assets and liabilities:                                              |     |                                 |     |   |         |     |   |         |
| Trade accounts receivable                                                                 |     |                                 |     |   | -17,546 |     |   | -13,336 |
| Prepaid expenses and other current assets                                                 |     |                                 |     |   |  -3,015 |     |   |  -3,350 |
| Inventory                                                                                 |     |                                 |     |   |  -5,951 |     |   | -15,275 |
| Accounts payable                                                                          |     |                                 |     |   |   3,362 |     |   |   1,629 |
| Other accrued liabilities                                                                 |     |                                 |     |   |   4,376 |     |   |    -398 |
| Accrued trade discounts and rebates                                                       |     |                                 |     |   |  21,707 |     |   |  20,375 |
| Accrued returns reserve                                                                   |     |                                 |     |   |  -1,295 |     |   |     134 |
| Operating lease liabilities                                                               |     |                                 |     |   |  -1,410 |     |   |  -1,154 |
| Other                                                                                     |     |                                 |     |   |   1,822 |     |   |   1,388 |
| Net cash provided by operating activities                                                 |     |                                 |     |   |  53,603 |     |   |   8,583 |
| Cash flows from investing activities:                                                     |     |                                 |     |   |         |     |   |         |
| Capital expenditures                                                                      |     |                                 |     |   |    -693 |     |   |    -363 |
| Net cash used in investing activities                                                     |     |                                 |     |   |    -693 |     |   |    -363 |
| Cash flows from financing activities:                                                     |     |                                 |     |   |         |     |   |         |
| Repayment of debt                                                                         |     |                                 |     |   | -23,074 |     |   |       — |
| Payments due upon exercise of stock appreciation rights                                   |     |                                 |     |   |  -2,825 |     |   |       — |
| Proceeds from issuance of employee stock purchase plan shares                             |     |                                 |     |   |   1,032 |     |   |     830 |
| Proceeds from exercise of stock options                                                   |     |                                 |     |   |   2,024 |     |   |  10,994 |
| Proceeds from issuance of common shares in settlement of warrants                         |     |                                 |     |   |   7,933 |     |   |   9,167 |
| Repurchase of common stock withheld for taxes                                             |     |                                 |     |   | -17,960 |     |   |  -9,336 |
| Net cash (used in) provided by financing activities                                       |     |                                 |     |   | -32,870 |     |   |  11,655 |
| Net increase in cash, cash equivalents, and restricted cash                               |     |                                 |     |   |  20,040 |     |   |  19,875 |
| Cash, cash equivalents and restricted cash, beginning of year                             |     |                                 |     |   | 115,063 |     |   |  75,744 |
| Cash, cash equivalents and restricted cash, end of quarter                                |     |                                 |     | $ | 135,103 |     | $ |  95,619 |
|                                                                                           |     |                                 |     |   |    2026 |     |   |    2025 |
| Supplemental schedule of cash flow information(1):                                        |     |                                 |     |   |         |     |   |         |
| Cash paid for interest                                                                    |     |                                 |     | $ |  17,505 |     | $ |  20,170 |
| Supplemental schedule of non-cash activities:                                             |     |                                 |     |   |         |     |   |         |
| Issuance of common shares in settlement of 2028 Convertible Debt                          |     |                                 |     | $ |  40,709 |     | $ |       — |
| Issuance of common shares in settlement of 2025 Convertible Debt                          |     |                                 |     | $ |       — |     | $ |  15,146 |
| Exercise of stock options                                                                 |     |                                 |     | $ |      31 |     | $ |     301 |

(1) There were no income taxes paid or refunds for the nine months ended September 30, 2026 and 2025.

<div align='center'>7</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

#### Condensed Consolidated Statements of Cash Flows
<div align='center'>(in thousands, unaudited)</div>

The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed consolidated balance sheets that agrees to the same amounts shown in the condensed consolidated statements of cash flows:

| Cash flows from operating activities:                                                                         |     |   | Nine Months Ended September 30, 
                            2026 |     |   |   2025 |
|:--------------------------------------------------------------------------------------------------------------|:----|:--|--------------------------------:|:----|:--|-------:|
| Cash and cash equivalents                                                                                     |     | $ |                         131,082 |     | $ | 91,598 |
| Restricted cash included in Other assets(1)                                                                   |     |   |                           4,021 |     |   |  4,021 |
| Total cash, cash equivalents and restricted cash shown in the condensed consolidated statements of cash flows |     | $ |                         135,103 |     | $ | 95,619 |

(1) These restricted cash items are primarily security deposits in the form of letters of credit for the Company to secure certain leases.

See accompanying notes to condensed consolidated financial statements.

<div align='center'>8</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

### Note 1. Organization and Business
Nature of Business

Xeris Biopharma Holdings, Inc. ("Xeris," "Xeris Biopharma" or the "Company") is a endocrine and rare disease biopharmaceutical company committed to helping people realize better lives through the development and commercialization of innovative medicines for serious diseases with significant unmet medical need. Xeris has three commercially available products: Recorlev, a cortisol synthesis inhibitor for the treatment of endogenous hypercortisolemia in patients with Cushing’s syndrome; Gvoke, a ready-to-use liquid glucagon for the treatment of severe hypoglycemia; and Keveyis, a proven therapy for primary periodic paralysis. Xeris also has a pipeline of development programs led by XP-8121, a Phase 3-ready, once-weekly subcutaneous levothyroxine injection for the treatment of hypothyroidism, as well as multiple early-stage programs leveraging Xeris’ technology platforms, XeriSol® and XeriJect®, for Xeris and its partners.

Throughout this document, unless otherwise noted, references to Gvoke include Gvoke PFS, Gvoke HypoPen, and Gvoke Kit (glucagon).

The Company relies on a number of single source suppliers and manufacturers for the supply of its products and product candidates.

Note 2. Basis of presentation and summary of significant accounting policies and estimates

Basis of presentation

The accompanying condensed consolidated financial statements are unaudited and have been prepared in accordance with accounting principles generally accepted in the United States of America ("GAAP"), including those for interim financial information, and with the instructions for Quarterly Reports on Form 10-Q and Article 10 of Regulation S-X issued by the U.S. Securities and Exchange Commission (the "SEC").

In the opinion of management, the accompanying condensed consolidated financial statements reflect all adjustments, consisting only of normal recurring adjustments, considered necessary for a fair presentation of the Company's financial position, results of operations and cash flows for the periods presented. The results of operations for such periods are not necessarily indicative of the results that may be expected for any future period. The accompanying financial statements should be read in conjunction with the audited financial statements and the related notes thereto for the year ended December 31, 2025 included in the Company's Annual Report on Form 10-K filed with the SEC on March 2, 2026.

Certain information and disclosures normally included in the annual financial statements prepared in accordance with GAAP, but that is not required for interim reporting purposes, have been condensed or omitted.

Any reference in these notes to applicable guidance is meant to refer to GAAP as found in the Accounting Standards Codification ("ASC") and Accounting Standards Update ("ASU") issued by the Financial Accounting Standards Board ("FASB").

Basis of consolidation

These condensed consolidated financial statements include the financial statements of Xeris and its subsidiaries. All intercompany transactions have been eliminated.

Use of estimates

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues and expenses included in the financial statements and accompanying notes. Actual results could differ from those estimates.

Revenue recognition

The Company applies the guidance in ASC Topic 606, Revenue from Contracts with Customers , to all contracts with customers within the scope of the standard.

The Company sells product primarily to wholesalers or a specialty pharmacy that subsequently resell to retail pharmacies or patients. The Company enters into arrangements with payors, group purchasing organizations, and healthcare providers that provide for government-mandated or privately-negotiated rebates, chargebacks and discounts related to the Company's products. The Company currently sells Recorlev, Gvoke, and Keveyis in the United States only.

Revenue is recognized when the Company's customer (e.g., a wholesaler or specialty pharmacy) obtains control of promised goods or services, which is when the Company's obligations under the terms of the contract with the customer are satisfied, based on the consideration the Company expects to receive in exchange for those goods or services.

Revenues are recorded at the net product sales price, which includes estimated allowances for patient copay assistance programs, prompt payment discounts, payor rebates, chargebacks, service fees, and product returns, all of which are recorded at the time of sale

<div align='center'>9</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

to the pharmaceutical wholesaler or other customer. The Company applies significant judgments and estimates in determining some of these allowances. If actual results differ from its estimates, adjustments are made to these allowances in the period in which the actual results or updates to estimates become known.

Such revenue is reported as product revenue, net in the condensed consolidated statements of operations and comprehensive income (loss).

Additionally, the Company earns revenue from research collaborations for the use of Xeris' proprietary formulation technology platforms and royalties from branded products. Such revenue is recognized as earned in accordance with contract terms when it can be reasonably estimated and collectability is reasonably assured. This revenue is reported as royalty, contract and other revenue in the condensed consolidated statements of operations and comprehensive income (loss). The aggregate amount of the transaction price allocated to research collaboration performance obligations that are unsatisfied as of the end of the reporting period is $ 6.2million. Of this amount, $3.9 million is expected to be recognized within the next twelve months and is included in other current liabilities, and the remaining $2.3 million is expected to be recognized beyond twelve months and is included in other liabilities (non-current) in the condensed consolidated balance sheets.

Concentration of credit risk

For the three and nine months ended September 30, 2026, four customers accounted for 98% of the Company's gross product revenue. For the three and nine months ended September 30, 2025, four customers accounted for 97% of the Company's gross product revenue. At September 30, 2026 and December 31, 2025, the same four customers accounted for 95% and 92% of the trade accounts receivable, net, respectively.

New accounting pronouncements

Adopted accounting standards

In November 2024, the FASB issued ASU 2024-04, Debt - Debt with Conversion and Other Options (Subtopic 470-20) - Induced Conversions of Convertible Debt Instruments . The FASB issued final guidance to clarify the requirements for determining whether to account for certain early settlements of convertible debt instruments as induced conversions. The guidance, which is based on a consensus-for-exposure of the Emerging Issues Task Force (EITF), is intended to address issues that stakeholders encountered when applying the guidance on induced conversions in Accounting Standards Codification (ASC or Codification) 470-20, Debt — Debt with Conversion and Other Options , to certain settlements of cash convertible debt instruments. For all entities, the guidance is effective for fiscal years beginning after December 15, 2025, and interim reporting periods within those fiscal years. Early adoption is permitted for all entities that have adopted ASU 2020-06, which simplified an issuer’s accounting for certain financial instruments with characteristics of liabilities and equity. The Company adopted this standard in the first quarter of 2026 and it did not have an immediate impact on the Company's Financial Statements and related disclosures.

Pending accounting standards

In November 2024, the FASB issued ASU 2024-03, Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures (Subtopic 220-40) , which requires disaggregated disclosure of income statement expenses for public business entities (PBEs). The ASU does not change the expense captions an entity presents on the face of the income statement; rather, it requires disaggregation of certain expense captions into specified categories in disclosures within the footnotes to the financial statements. ASU 2024-03 is effective for all PBEs for fiscal years beginning after December 15, 2026, and interim periods within fiscal years beginning after December 15, 2027. Early adoption is permitted. The Company is evaluating the timing and effects of the adoption of this standard on the Company's disclosures.

<div align='center'>10</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

#### Note 3. Disaggregated Revenue
Disaggregated revenue by product (in thousands):

| Product revenue:                    |     |   | Three Months Ended September 30, 
                             2026 |     |   |   2025 |     |   | Nine Months Ended September 30, 
                            2026 |     |   |    2025 |
|:------------------------------------|:----|:--|---------------------------------:|:----|:--|-------:|:----|:--|--------------------------------:|:----|:--|--------:|
| Recorlev                            |     | $ |                           71,540 |     | $ | 36,975 |     | $ |                         178,088 |     | $ |  93,949 |
| Gvoke                               |     |   |                           21,706 |     |   | 25,151 |     |   |                          65,055 |     |   |  69,463 |
| Keveyis                             |     |   |                           13,021 |     |   | 11,937 |     |   |                          36,582 |     |   |  34,849 |
| Other product revenue               |     |   |                                — |     |   |      — |     |   |                               — |     |   |   1,312 |
| Product revenue, net                |     |   |                          106,267 |     |   | 74,063 |     |   |                         279,725 |     |   | 199,573 |
| Royalty, contract and other revenue |     |   |                              958 |     |   |    317 |     |   |                           2,727 |     |   |   6,465 |
| Total revenue                       |     | $ |                          107,225 |     | $ | 74,380 |     | $ |                         282,452 |     | $ | 206,038 |

#### Note 4. Inventory
The components of inventory consist of the following (in thousands):

|                 |     |   | September 30, 2026 |     |   | December 31, 2025 |
|:----------------|:----|:--|-------------------:|:----|:--|------------------:|
| Raw materials   |     | $ |             40,862 |     | $ |            38,010 |
| Work in process |     |   |             11,055 |     |   |            11,295 |
| Finished goods  |     |   |             25,008 |     |   |            19,368 |
| Inventory, net  |     | $ |             76,925 |     | $ |            68,673 |

Inventory reserves were $ 15.6million and $ 7.6million at September 30, 2026 and December 31, 2025, respectively.

#### Note 5. Property and Equipment
Property and equipment consist of the following (in thousands):

|                                                 |     |   | September 30, 2026 |     |   | December 31, 2025 |
|:------------------------------------------------|:----|:--|-------------------:|:----|:--|------------------:|
| Lab equipment                                   |     | $ |              5,178 |     | $ |             5,325 |
| Furniture and fixtures                          |     |   |                545 |     |   |               545 |
| Computer equipment                              |     |   |              1,218 |     |   |               946 |
| Office equipment                                |     |   |                 97 |     |   |                97 |
| Software                                        |     |   |                904 |     |   |               514 |
| Leasehold improvements                          |     |   |              5,695 |     |   |             5,695 |
| Total property and equipment                    |     |   |             13,637 |     |   |            13,122 |
| Less: accumulated depreciation and amortization |     |   |             -8,999 |     |   |            -8,177 |
| Property and equipment, net                     |     | $ |              4,638 |     | $ |             4,945 |

Depreciation and amortization expense relating to property and equipment was $ 0.3million for each of the three months ended September 30, 2026 and 2025. Depreciation and amortization expense relating to property and equipment was $ 1.0million for each of the nine months ended September 30, 2026 and 2025.

<div align='center'>11</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

#### Note 6. Intangible Assets
Identified intangible assets consist of the following (in thousands):

|                                            |     |              |     |   | September 30, 2026 |     |   |                          |     |   |        |     |   | December 31, 2025 |     |   |                          |     |   |        |
|:-------------------------------------------|:----|-------------:|:----|:--|-------------------:|:----|:--|-------------------------:|:----|:--|-------:|:----|:--|------------------:|:----|:--|-------------------------:|:----|:--|-------:|
|                                            |     | Life (Years) |     |   |       Gross assets |     |   | Accumulated amortization |     |   |    Net |     |   |      Gross assets |     |   | Accumulated amortization |     |   |    Net |
| Definite-lived intangible asset - Keveyis  |     |            5 |     | $ |             11,000 |     | $ |                  -11,000 |     | $ |      — |     | $ |            11,000 |     | $ |                   -9,350 |     | $ |  1,650 |
| Definite-lived intangible asset - Recorlev |     |           14 |     |   |            121,000 |     |   |                  -41,054 |     |   | 79,946 |     |   |           121,000 |     |   |                  -34,572 |     |   | 86,428 |
| Total intangible assets                    |     |              |     | $ |            132,000 |     | $ |                  -52,054 |     | $ | 79,946 |     | $ |           132,000 |     | $ |                  -43,922 |     | $ | 88,078 |

As of September 30, 2026, expected amortization expense for intangible assets subject to amortization for the next five years and thereafter is as follows (in thousands):

| 2026       |     | $ |  2,161 |
| 2027       |     |   |  8,643 |
| 2028       |     |   |  8,643 |
| 2029       |     |   |  8,643 |
| 2030       |     |   |  8,643 |
| Thereafter |     |   | 43,213 |
| Total      |     | $ | 79,946 |

#### Note 7. Other Accrued Liabilities
Other accrued liabilities consist of the following (in thousands):

|                                        |     |   | September 30, 2026 |     |   | December 31, 2025 |
|:---------------------------------------|:----|:--|-------------------:|:----|:--|------------------:|
| Accrued employee costs                 |     | $ |             33,496 |     | $ |            24,061 |
| Accrued interest expense               |     |   |                481 |     |   |               505 |
| Accrued supply chain costs             |     |   |                769 |     |   |               370 |
| Accrued marketing costs                |     |   |              2,102 |     |   |             1,402 |
| Accrued research and development costs |     |   |              5,559 |     |   |             3,467 |
| Accrued other costs                    |     |   |              4,959 |     |   |             3,350 |
| Other accrued liabilities              |     | $ |             47,366 |     | $ |            33,155 |

#### Note 8. Debt
The components of debt are as follows (in thousands):

|                                                           |     |   | September 30, 2026 |     |   | December 31, 2025 |
|:----------------------------------------------------------|:----|:--|-------------------:|:----|:--|------------------:|
| Convertible senior notes                                  |     | $ |                  — |     | $ |            33,894 |
| Less: unamortized debt issuance costs                     |     |   |                  — |     |   |              -628 |
| Loan agreement                                            |     |   |            191,064 |     |   |           188,768 |
| Less: unamortized debt issuance costs                     |     |   |             -1,351 |     |   |            -1,699 |
| Debt, net of unamortized debt issuance costs, non-current |     | $ |            189,713 |     | $ |           220,335 |

Convertible Senior Notes

In September 2023, the Company completed the exchange of $ 32.0million in aggregate principal amount of its then outstanding Convertible Notes due 2025 ("2025 Convertible Notes") for $ 33.6million in aggregate principal amount of new 8.00% Convertible Notes due 2028 (the "2028 Convertible Notes").

<div align='center'>12</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

In March and April of 2025, holders of all outstanding 2025 Convertible Notes, totaling $ 15.2million in aggregate principal amount, were converted by the noteholders into 4,978,151shares of the Company's common stock.

The 2028 Convertible Notes were senior, unsecured obligations and are equal in right of payment with the issuer's existing and future senior, unsecured indebtedness, senior in right of payment to its future indebtedness, if any, that is expressly subordinated to the 2028 Convertible Notes, and effectively subordinated to its existing and future secured indebtedness to the extent of the value of the collateral securing that indebtedness. The 2028 Convertible Notes were structurally subordinated to all existing and future indebtedness and other liabilities, including trade payables, and (to the extent the Company or Xeris Pharma is not a holder thereof) preferred equity, if any, of the Company's direct and indirect subsidiaries other than Xeris Pharma.

At any time before the close of business on the second scheduled trading day immediately before the maturity date, holders of the then outstanding 2028 Convertible Notes had the option to convert their 2028 Convertible Notes into shares of the Company's common stock, together, if applicable, with cash in lieu of any fractional share, at a conversion rate of 326.7974 shares of the Company's common stock per $1,000 principal amount of 2028 Convertible Notes, subject to adjustment in certain circumstances.

In June 2026, the Company executed an exchange agreement to enable settlement in cash of $ 23.1million in aggregate principal outstanding with certain holders of their 2028 Convertible Notes. Execution of this exchange agreement resulted in recognition of an extinguishment loss of $ 30.8million, which represents the difference between the amortized cost of this component of the 2028 Convertible Notes immediately prior to the exchange and their fair value of $53.7 million.

In July 2026, the Company settled its obligations with the noteholders of the 2028 Convertible Notes, after which nonotes remain outstanding. The settlement was completed by issuing 8.6million shares of the Company's common stock and $ 23.1million of cash.

Loan Agreement

On March 5, 2024, the Company and certain subsidiary guarantors of the Company entered into an Amended and Restated Credit Agreement and Guaranty (the "Amended and Restated Credit Agreement") with the lenders from time to time parties thereto (the "Lenders") and Hayfin Services LLP, as administrative agent for the Lenders, pursuant to which the Company and its subsidiaries party thereto granted a first priority security interest on substantially all of their assets, including intellectual property, subject to certain exceptions. The Amended and Restated Credit Agreement amends and restates in its entirety the Credit Agreement dated March 8, 2022, between the Company, Xeris Pharma, and certain subsidiary guarantors of the Company and Hayfin Services, LLP, as administrative agent for the lenders ("Credit Agreement"). The Amended and Restated Credit Agreement provided for the Lenders to extend $ 200.0million in term loans (the "Tranche 1 Loans") to Xeris Pharma on the closing date and $ 15.2million in additional term loans (the "Tranche 2 Loans" and, together with the Tranche 1 Loans, the "2029 Loans") on any date after the closing date and through July 15, 2025. The Tranche 2 Loans were only to be used to redeem the then outstanding 2025 Convertible Notes. The Company did not borrow any funds under the Tranche 2 Loans, which expired on July 15, 2025. In conjunction with the execution of the Amended and Restated Credit Agreement, the aggregate principal balance of $ 150.0million plus all accrued and unpaid interest outstanding under the Credit Agreement was continued under the Amended and Restated Credit Agreement as Tranche 1 Loans. In addition to utilizing the proceeds to repay the obligations under the Credit Agreement in full, the proceeds of the Tranche 1 Loans are being used for general corporate purposes. After repayment, the 2029 Loans may not be re-borrowed. The 2029 Loans will mature on March 5, 2029.

The 2029 Loans incur interest at a floating per annum rate in an amount equal to the sum of (i) 6.95% (or 5.95% if the replacement rate is in effect) plus (ii) the greater of (x) the forward-looking term rate based on SOFRfor a three month tenor (or the replacement rate, if applicable), and (y) 2.00% per annum. The remaining balance of unamortized debt issuance costs have been reflected as a direct reduction to the loan balance. The effective interest rate of the 2029 Loans, including the amortization of debt discount and debt issuance costs, amounts to approximately 11.4%. As of September 30, 2026, the fair value of the loan approximates its book value.

The Amended and Restated Credit Agreement allows Xeris Pharma to voluntarily prepay the outstanding amounts thereunder. Xeris Pharma is subject to an early prepayment fee equal to (i) for any prepayment that occurs on or prior to the second anniversary of the closing date, the applicable make-whole amount, (ii) for any prepayment that occurs after the second anniversary of the closing date but on or prior to the fourth anniversary of the closing date, the product of (x) the amount of any principal so prepaid, multiplied by (y) for any prepayment that occurs (A) after the second anniversary of the closing date and on or prior to the third anniversary of the closing date, five percent ( 5.00%), (B) after the third anniversary of the closing date and on or prior to the fourth anniversary of the closing date, three percent ( 3.00%), and (C) after the fourth anniversary of the closing date, zero percent ( 0.00%).

The Amended and Restated Credit Agreement contains customary representations and warranties, events of default and affirmative and negative covenants, including, among others, covenants that limit or restrict the Company's (and its subsidiaries) ability to incur additional indebtedness, grant liens, merge or consolidate, make acquisitions, pay dividends or other distributions or repurchase equity, make investments, dispose of assets and enter into certain transactions with affiliates, in each case subject to certain exceptions.

<div align='center'>13</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

The Amended and Restated Credit Agreement was accounted for as a modification of debt in accordance with ASC 470-50, Debt - Modifications and Extinguishments , thus there was no gain or loss recognized on the transaction.

The following table sets forth the Company's future minimum principal payments on the 2029 Loans (in thousands):

| 2026       |     | $ |       — |
| 2027       |     |   |       — |
| 2028       |     |   |       — |
| 2029       |     |   | 200,000 |
| 2030       |     |   |       — |
| Thereafter |     |   |       — |
|            |     | $ | 200,000 |

For the three months ended September 30, 2026 and 2025, the Company recognized interest expense of $ 6.5million and $ 7.3million, respectively, of which $ 0.9million and $ 0.8million, respectively, related to the amortization of debt discount and issuance costs, respectively. For the nine months ended September 30, 2026 and 2025, the Company recognized interest expense of $ 20.3million and $ 21.9million, respectively, of which $ 2.7million and $ 2.5million, respectively, related to the amortization of debt discount and issuance costs, respectively.

#### Note 9. Warrants
As of September 30, 2026, the following equity classified warrants were outstanding:

| Warrants classified as equities:                              |     | Outstanding Warrants |         |     | Exercise Price per Warrant |     | Expiration    
 Date          |
| Warrants in connection with Horizon and Oxford loan agreement |     |                      | 125,999 |     |                     $3.130 |     | December 2026 |

In January 2026, the Company issued an aggregate of 2,275,313shares of its common stock pursuant to a notice of cash exercise of all warrants previously held by Armistice Capital for an aggregate purchase price of $ 7.3million.

In June 2026, the Company issued an aggregate of 263,158 shares of its common stock pursuant to a notice of cash exercise of all warrants previously held by Hayfin for an aggregate purchase price of $0.6 million.

#### Note 10. Fair Value Measurements
Fair value is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. Fair value measurements are classified and disclosed in one of the following categories:

Level 1: Measured using unadjusted quoted prices in active markets that are accessible at the measurement date for identical, unrestricted assets or liabilities.

Level 2: Measured using quoted prices in active markets for similar assets or liabilities, quoted prices for identical or similar assets or liabilities in markets that are not active, or inputs, other than quoted prices in active markets, that are observable either directly or indirectly.

Level 3: Measured based on prices or valuation models that require inputs that are both significant to the fair value measurement and less observable from objective sources (i.e., supported by little or no market activity).

Fair value measurements are classified based on the lowest level of input that is significant to the measurement. The Company's assessment of the significance of a particular input to the fair value measurement requires judgment, which may affect the valuation of the assets and liabilities and their placement within the fair value hierarchy levels. The determination of the fair values stated below considers the market for the financial assets and liabilities, the associated credit risk and other factors as required. The Company considers active markets as those in which transactions for the assets or liabilities occur in sufficient frequency and volume to provide pricing information on an ongoing basis.

<div align='center'>14</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

The following tables present the Company's fair value hierarchy for those assets and liabilities measured at fair value as of September 30, 2026 and December 31, 2025 (in thousands):

|                             |     |   |        Total as of 
 September 30, 2026 |     |   | Level 1 |     |   | Level 2 |     |   | Level 3 |
|:----------------------------|:----|:--|-------------------:|:----|:--|--------:|:----|:--|:--------|:----|:--|:--------|
| Assets                      |     |   |                    |     |   |         |     |   |         |     |   |         |
| Cash and cash equivalents:  |     |   |                    |     |   |         |     |   |         |     |   |         |
| Cash and money market funds |     | $ |            131,082 |     | $ | 131,082 |     | $ | —       |     | $ | —       |
| Other assets:               |     |   |                    |     |   |         |     |   |         |     |   |         |
| Restricted cash             |     | $ |              4,021 |     | $ |   4,021 |     | $ | —       |     | $ | —       |

|                             |     |   | Total as of December 31, 2025 |     |   | Level 1 |     |   | Level 2 |     |   | Level 3 |
|:----------------------------|:----|:--|------------------------------:|:----|:--|--------:|:----|:--|:--------|:----|:--|:--------|
| Assets                      |     |   |                               |     |   |         |     |   |         |     |   |         |
| Cash and cash equivalents:  |     |   |                               |     |   |         |     |   |         |     |   |         |
| Cash and money market funds |     | $ |                       111,042 |     | $ | 111,042 |     | $ | —       |     | $ | —       |
| Other assets:               |     |   |                               |     |   |         |     |   |         |     |   |         |
| Restricted cash             |     | $ |                         4,021 |     | $ |   4,021 |     | $ | —       |     | $ | —       |

#### Note 11. Stock Compensation Plans
The 2018 Stock Option and Incentive Plan (the "2018 Plan") was adopted by the Board of Directors in April 2018 and approved by the Company's stockholders in June 2018. The 2018 Plan replaced the 2011 Plan as the Board of Directors decided not to make additional awards under the 2011 Stock Option Issuance Plan (the "2011 Plan"). Under the 2018 Plan, equity awards may be granted to the Company's officers, employees, directors, consultants and advisors. As of September 30, 2026, there were 10.8million shares of common stock available for future issuance under the 2018 Plan.

The 2018 Employee Stock Purchase Plan (as amended, the "ESPP") was adopted by the Board of Directors in April 2018, approved by the Company's stockholders in June 2018, and subsequently amended by the Company's stockholders in June 2024. The ESPP permits eligible employees to authorize payroll deductions of up to 15% of their compensation to purchase up to the number of shares of common stock determined by dividing $ 25,000by the closing market price of Xeris common stock on the offering date. The purchase price per share at each purchase date is equal to 85% of the lower of (i) the closing market price per share of Xeris common stock on the employee's offering date or (ii) the closing market price per share of Xeris common stock on the purchase date. Each offering period has a six-monthduration and purchase interval. As of September 30, 2026, there were 5.7million shares available for issuance under the ESPP.

The Equity Inducement Plan (the "Inducement Plan") was adopted by the Board of Directors in February 2019. Under the Inducement Plan, the Company may grant share-based awards to individuals who were not previously employees, or following a bona fide period of nonemployment, as an inducement to such individuals entering into employment with the Company. As of September 30, 2026, there were 0.3million shares of common stock available for future issuance under the Inducement Plan.

Assumed Plans

As of September 30, 2026, there were no shares reserved for future grants under the legacy equity incentive plans of Strongbridge, including the Strongbridge 2015 equity compensation plan and Strongbridge 2017 inducement plan (collectively, the "Assumed Plans").

<div align='center'>15</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

Stock Options

Stock options are granted with an exercise price equal to the market price of the Company's common stock at the date of grant. Stock option awards typically vest over three yearsafter the grant date and expire sevento ten yearsfrom the grant date.

Stock option activity under the 2011 Plan, 2018 Plan, Inducement Plan and Assumed Plans for the nine months ended September 30, 2026:

|                                  |     | Number of Options |     | Weighted Average Exercise Price 
 Per Share                       |       |     | Weighted Average Contractual Life (years) |      |     | Aggregate Intrinsic Value (in thousands) |         |
| Outstanding - December 31, 2025  |     |         5,309,859 |     |                                 | $5.54 |     |                                           | 2.78 |     |                                          | $16,253 |
| Granted                          |     |         2,573,953 |     |                                 | $7.29 |     |                                           |      |     |                                          |         |
| Exercised                        |     |          -739,515 |     |                                 | $2.78 |     |                                           |      |     |                                          |         |
| Forfeited                        |     |           -24,324 |     |                                 | $7.36 |     |                                           |      |     |                                          |         |
| Expired                          |     |          -194,680 |     |                                 | $7.58 |     |                                           |      |     |                                          |         |
| Outstanding - September 30, 2026 |     |         6,925,293 |     |                                 | $6.42 |     |                                           | 4.92 |     |                                          | $24,078 |
| Exercisable - September 30, 2026 |     |         4,375,664 |     |                                 | $5.92 |     |                                           | 2.33 |     |                                          | $18,289 |

Intrinsic value for stock options is defined as the difference between the current market value of the Company's common stock and the exercise price.

Stock options value assumptions:

|                                 |     | Nine Months Ended September 30, |
|                                 |     |                            2026 |
| Expected term (in years)        |     |                             6.5 |
| Risk-free interest rate         |     |                            4.0% |
| Expected stock price volatility |     |                           81.8% |
| Expected dividend yield         |     |                              —% |

No stock options were granted during the nine months ended September 30, 2025.

As of September 30, 2026, there was $ 10.7million of unrecognized stock-based compensation expense related to stock options, which is expected to be recognized over the weighted-average remaining vesting period of 2.2years.

<div align='center'>16</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

Restricted Stock Units

Restricted Stock Units ("RSUs") generally vest over three yearsin equal annual installments beginning on the one-year anniversary of the date of grant, subject to continued service through the vesting date. The Company withholds upon settlement as RSUs vest, or as stock options are exercised, the portion of those shares with a fair market value equal to the amount of the minimum statutory withholding taxes due. The withheld shares are accounted for as repurchases of common stock. Stock-based compensation expense related to RSUs is recognized on a straight-line basis over the grantee's requisite service period.

A summary of outstanding RSU awards and the activity for the nine months ended September 30, 2026:

|                                       |     | Number of Units |            |     |   | Weighted Average Grant Date Fair Value 
                              Per Share |
|:--------------------------------------|:----|----------------:|-----------:|:----|:--|---------------------------------------:|
| Unvested balance - December 31, 2025  |     |                 | 13,511,338 |     | $ |                                   2.93 |
| Granted                               |     |       3,577,887 |            |     | $ |                                   7.24 |
| Vested                                |     |      -6,753,139 |            |     | $ |                                   2.49 |
| Forfeited                             |     |      -1,090,272 |            |     | $ |                                   3.96 |
| Unvested balance - September 30, 2026 |     |                 |  9,245,814 |     | $ |                                   4.80 |

The total fair value of RSUs vested for the nine months ended September 30, 2026 was $ 49.2million. Of the vested RSUs, 2.4million shares were surrendered to fulfill tax withholding obligations.

As of September 30, 2026, there was $ 30.6million of unrecognized stock-based compensation expense related to RSUs, which is expected to be recognized over the weighted-average remaining vesting period of 1.5years. For the nine months ended September 30, 2026 and September 30, 2025, the weighted-average grant date fair value per share of RSUs granted was $ 7.24and $ 3.73, respectively.

Stock Appreciation Rights

Stock appreciation rights ("SARs") are granted under the 2018 Plan. SARs are granted with an exercise price equal to the market price of the Company's common stock at the date of grant. SARs allow the recipient to receive the appreciation in the fair market value of the Company's common stock between the exercise date and the date of grant. SARs are settled in cash and vest in full and automatically exercise on the second anniversary of the date of grant, subject to continued service through the vesting date. SARs are settled in cash, and accordingly are classified as liabilities in the Company's Condensed Consolidated Balance Sheets and are remeasured to fair value at the end of each reporting period using the Black-Scholes option-pricing model.

SARs activity under the 2018 Plan for the nine months ended September 30, 2026 was as follows:

|                                              |     | Number of SARs |     |   | Weighted Average Exercise Price 
                       Per Share |     | Weighted Average Remaining Contractual Life (in years) |      |     |   | Aggregate Intrinsic Value (in thousands) |        |
|:---------------------------------------------|:----|---------------:|:----|:--|--------------------------------:|:----|:-------------------------------------------------------|-----:|:----|:--|:-----------------------------------------|-------:|
| Outstanding - December 31, 2025              |     |      2,650,000 |     | $ |                            3.36 |     |                                                        | 0.98 |     | $ |                                          | 11,752 |
| Granted                                      |     |              — |     | $ |                               — |     |                                                        |      |     |   |                                          |        |
| Exercised                                    |     |       -500,000 |     | $ |                            2.43 |     |                                                        |      |     |   |                                          |        |
| Outstanding - September 30, 2026             |     |      2,150,000 |     | $ |                            3.63 |     |                                                        | 0.35 |     | $ |                                          | 12,718 |
| Vested and exercisable at September 30, 2026 |     |              — |     | $ |                               — |     |                                                        |      |     |   |                                          |        |

<div align='center'>17</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

SARs fair value for the nine months ended September 30, 2026 (in thousands):

|                               |     |   | Fair Value |
|:------------------------------|:----|:--|-----------:|
| Balance at December 31, 2025  |     | $ |      6,313 |
| Change in fair value of SARs  |     |   |      7,120 |
| Payment of SARs               |     |   |     -2,825 |
| Balance at September 30, 2026 |     | $ |     10,608 |

SARs value assumptions:

|                                 |     | Nine Months Ended September 30, |
|                                 |     |                            2026 |
| Expected term (in years)        |     |                            0.35 |
| Risk-free interest rate         |     |                            4.3% |
| Expected stock price volatility |     |                           47.7% |
| Expected dividend yield         |     |                              —% |

The risk-free interest rate for SARs is based on the United States Treasury yield curve in effect at the time of remeasurement. Expected stock price volatility is based on the historical volatility of the Company's stock. As of September 30, 2026, there was $ 2.2million of unrecognized stock-based compensation expense related to SARs.

Stock-based Compensation Expense

The following table summarizes the reporting of total stock-based compensation expense resulting from stock options, RSUs, SARs, and the ESPP (in thousands):

|                                        |     |   | Three Months Ended September 30, 
                             2026 |     |   |  2025 |     |   | Nine Months Ended September 30, 
                            2026 |     |   |   2025 |
|:---------------------------------------|:----|:--|---------------------------------:|:----|:--|------:|:----|:--|--------------------------------:|:----|:--|-------:|
| Research and development               |     | $ |                              561 |     | $ |   421 |     | $ |                           1,703 |     | $ |  1,189 |
| Selling, general and administrative    |     | $ |                           10,241 |     | $ | 7,222 |     | $ |                          24,305 |     | $ | 15,905 |
| Total stock-based compensation expense |     | $ |                           10,802 |     | $ | 7,643 |     | $ |                          26,008 |     | $ | 17,094 |

#### Note 12. Leases
The Company has non-cancellable operating leases for office and laboratory space, which expire at various times in 2031 and 2036. The non-cancellable lease agreements provide for monthly lease payments, which increase during the term of each lease agreement.

All of the Company's leases are classified as operating leases, which are included as operating lease right-of-use assets and current and non-current operating lease liabilities in the condensed consolidated balance sheets. The Company's operating lease costs are included in operating expenses in the accompanying condensed consolidated statements of operations and comprehensive income (loss). The Company's lease agreements do not contain any material residual value guarantees or material restrictive covenants.

A majority of the Company's lease agreements include fixed rental payments. Certain lease agreements include fixed rental payments that are adjusted periodically by a fixed rate. The fixed payments, including the effects of changes in the fixed rate or amount, and renewal options reasonably certain to be exercised, are included in the measurement of the related lease liability. The exercise of lease renewal options is at the Company's sole discretion. The depreciable life of assets and leasehold improvements are limited by the expected lease term, which includes renewal options reasonably certain to be exercised. The majority of the Company's real estate leases require that the Company pay maintenance, real estate taxes and insurance in addition to rent. These payments are generally variable and based on actual costs incurred by the lessor. Therefore, these amounts are not included in the consideration of the contract when determining the right-of-use asset and lease liability but are reflected as variable lease expenses.

As the interest rate implicit in the lease is not readily determinable, the Company uses the incremental borrowing rate as the discount rate. The Company considers observable inputs as of the effective date of the ASC 842 adoption including the credit rating, existing borrowings and other relevant borrowing rates, such as risk-free rates like the United States Treasury rate, and then adjusting as necessary for the appropriate lease term. The incremental borrowing rate is reassessed if there is a change to the lease term or if a

<div align='center'>18</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

modification occurs and it is not accounted for as a separate contract. As of September 30, 2026, the Company's operating leases had a weighted-average remaining lease term of 9.0years and a weighted-average discount rate of 12.0%.

Supplemental cash flow information related to the Company's operating leases was as follows (in thousands):

| Cash paid for amounts included in the measurement of lease liabilities: |     |   | Three Months Ended September 30, 
                             2026 |     |   |  2025 |     |   | Nine Months Ended September 30, 
                            2026 |     |   |  2025 |
|:------------------------------------------------------------------------|:----|:--|---------------------------------:|:----|:--|------:|:----|:--|--------------------------------:|:----|:--|------:|
| Operating cash flows for operating leases                               |     | $ |                            1,570 |     | $ | 1,531 |     | $ |                           4,663 |     | $ | 4,548 |

The Company reports the amortization of operating lease right-of-use assets and the change in operating lease liabilities on a net basis in other in the operating activities of the accompanying consolidated statements of cash flows.

The components of lease expense were as follows (in thousands):

| Lease expense           |     |   | Three Months Ended September 30, 
                             2026 |     |   |  2025 |     |   | Nine Months Ended September 30, 
                            2026 |     |   |  2025 |
|:------------------------|:----|:--|---------------------------------:|:----|:--|------:|:----|:--|--------------------------------:|:----|:--|------:|
| Operating lease expense |     | $ |                            1,284 |     | $ | 1,298 |     | $ |                           3,770 |     | $ | 3,865 |
| Variable lease expense  |     |   |                              985 |     |   |   986 |     |   |                           2,950 |     |   | 2,935 |
| Sublease income         |     |   |                             -179 |     |   |  -216 |     |   |                            -717 |     |   |  -800 |
| Total lease expense     |     | $ |                            2,090 |     | $ | 2,068 |     | $ |                           6,003 |     | $ | 6,000 |

The operating and variable lease expenses are reported within operating expenses while sublease income is reported in interest and other income.

As of September 30, 2026, maturities of lease liabilities are summarized as follows (in thousands):

| 2026                                             |     | $ |   1,570 |
| 2027                                             |     |   |   6,389 |
| 2028                                             |     |   |   6,549 |
| 2029                                             |     |   |   6,714 |
| 2030                                             |     |   |   6,883 |
| Thereafter                                       |     |   |  31,844 |
| Total lease payments                             |     |   |  59,949 |
| Less: Effect of discounting to net present value |     |   | -23,596 |
| Present value of lease liabilities               |     | $ |  36,353 |
| Operating lease liabilities, current             |     |   |   6,349 |
| Operating lease liabilities, non-current         |     |   |  30,004 |
| Total operating lease liabilities                |     | $ |  36,353 |

<div align='center'>19</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

#### Note 13. Commitments and Contingencies
Commitments

Commitments to Taro

The Company has a supply agreement with Taro Pharmaceuticals North America, Inc. ("Taro") to produce Keveyis. In 2023, the Company amended the agreement to extend the initial term until March 2027. As part of the agreement, as amended, the Company has agreed to certain annual minimum marketing spend requirements and minimum purchase order quantities for each year, which in the case of the minimum purchase order quantities, is based on the previous year's purchases.

Leases

As of September 30, 2026, the Company had unused letters of credit of $ 4.0million, which were issued primarily to secure leases. These letters of credit are collateralized by $ 4.0million of restricted cash, which is recorded in other assets in the condensed consolidated balance sheets.

Contingencies

Legal Matters

On February 26, 2026, March 20, 2026, June 4, 2026, and July 13, 2026, the Company’s wholly owned subsidiaries, Xeris Pharmaceuticals, Inc. and Strongbridge Dublin Limited, filed patent infringement lawsuits under the Hatch-Waxman Act in the United States District Court for the District of New Jersey against defendants (i) Torrent Pharmaceuticals Limited (along with its affiliate, “Torrent”) and Somerset Therapeutics, LLC (along with its affiliates, “Somerset”), (ii) Sandoz Inc. (“Sandoz”) and Zydus Lifesciences Global FZE (along with its affiliates, “Zydus”), and (iii) Novitium Pharma, LLC (along with its affiliate, “Novitium”) in two separate actions, respectively (each, an “ANDA Filer”). These lawsuits were filed following receipt of a Paragraph IV certification notice letter (each, a “Notice Letter”) from each of Torrent, Somerset, Sandoz, Zydus, and Novitium regarding the filing of its respective Abbreviated New Drug Application (“ANDA”) with the U.S. Food and Drug Administration (“FDA”) seeking approval to manufacture, use, or sell a generic version of Recorlev®. The Notice Letters stated that each ANDA Filer’s ANDAs contained Paragraph IV certifications alleging that four of the Company’s Orange Book-listed patents covering Recorlev® (U.S. Patent Nos. 11,020,393, 11,278,547, 11,903,940 and 12,377,096) (collectively, the “Orange Book Patents”), which are scheduled to expire in March 2040, are invalid, unenforceable and/or will not be infringed by each ANDA Filer’s manufacture, use, or sale of the generic product described in its respective ANDA submission.

Collectively, the complaints allege that, by filing ANDAs for their respective generic products, each of Torrent, Somerset, Sandoz, Zydus, and Novitium has infringed the Orange Book Patents for Recorlev®. The complaints seek an order preventing the FDA from granting final approval of the respective ANDAs before the expiration of the Orange Book Patents and a permanent injunction to prevent each of the defendants from commercializing a generic version of Recorlev®, until the expiration of the Orange Book Patents, including any applicable extensions and additional periods of exclusivity. On June 8, 2026, the United States District Court for the District of New Jersey entered an order consolidating for all pretrial purposes the actions filed on February 26, 2026 against Somerset and Torrent and the action filed on March 20, 2026 against Sandoz and Zydus (“Consolidated Action”). On July 20, 2026, the United States District Court for the District of New Jersey entered an order consolidating for all pretrial purposes the actions against Novitium filed on June 4, 2026 and July 13, 2026 into the Consolidated Action. A bench trial has been tentatively scheduled for November 2028. The filing of each lawsuit within 45 days of receipt of each of the respective Notice Letters triggered an automatic stay of the FDA’s approval of each of the respective ANDAs in accordance with the Hatch-Waxman Act until up to June 30, 2029, in the absence of a decision from the court finding all asserted claims invalid or not infringed before that date.

The Company may receive additional Notice Letters in the future from ANDA filers seeking approval of a generic version of Recorlev and may file additional ANDA lawsuits in the future.

On October 13, 2026, the Company, through its wholly owned subsidiary, Xeris Pharmaceuticals, Inc., filed patent infringement lawsuits in the United States District Court for the District of New Jersey against defendants (i) Torrent Pharma Inc., Torrent Pharmaceuticals Limited, Cycle Pharmaceuticals Limited, Lemed Pharmacy III, LLC, and Lemed Specialty Pharmacy Arizona, LLC; and (ii) Rising Pharma Holdings, Inc. and Rising Pharma Specialties Pvt. Ltd. in two separate actions. These lawsuits were filed following the grant of U.S. Patent No. 12,758,502 (the “’502 patent”) related to the Company’s KEVEYIS® (dichlorphenamide) product.

The complaints allege that each of the defendants will infringe the ’502 patent by making, using, selling, offering for sale, and/or importing their generic dichlorphenamide products. The Company is seeking a judgment of infringement, injunctive relief prohibiting further infringement, monetary damages adequate to compensate for the infringement, enhanced damages where permitted by law, attorneys’ fees, costs, and such other relief as the court deems appropriate.

<div align='center'>20</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

From time to time, the Company may become involved in various other legal actions arising in the ordinary course of business. As of September 30, 2026, management was not aware of any other existing, pending or threatened legal actions that would have a material adverse impact on the financial position or results of operations of the Company.

#### Note 14. Net Income (Loss) Per Common Share
Basic and diluted net income (loss) per common share are determined by dividing net income (loss) applicable to common stockholders by the weighted average common shares outstanding during the period. For periods in which the Company was in a net loss, the shares issuable upon conversion, exercise or vesting of Convertible Notes, warrants, stock option awards and RSUs have been excluded from the calculation because their effects would be anti-dilutive. Therefore, the weighted average common shares outstanding used to calculate both basic and diluted net loss per common share are the same.

A reconciliation of the numerator and denominator used in the calculation of basic and diluted net income (loss) per share is as follows (in thousands):

| Numerator (basic and diluted):                                              |     |   | Three months ended September 30, 
                             2026 |     |   |        2025 |     |   | Nine Months Ended September 30, 
                            2026 |     |   |        2025 |
|:----------------------------------------------------------------------------|:----|:--|---------------------------------:|:----|:--|------------:|:----|:--|--------------------------------:|:----|:--|------------:|
| Net income (loss)                                                           |     | $ |                           11,290 |     | $ |         621 |     | $ |                         -17,577 |     | $ |     -10,527 |
| Denominator:                                                                |     |   |                                  |     |   |             |     |   |                                 |     |   |             |
| Weighted-average shares outstanding for basic net income (loss) per share   |     |   |                      180,941,748 |     |   | 163,649,932 |     |   |                     174,800,967 |     |   | 158,559,467 |
| Effect of dilutive securities:                                              |     |   |                                  |     |   |             |     |   |                                 |     |   |             |
| RSUs                                                                        |     |   |                        5,675,998 |     |   |   9,829,642 |     |   |                               — |     |   |           — |
| Stock Options                                                               |     |   |                        1,746,477 |     |   |   2,041,961 |     |   |                               — |     |   |           — |
| Warrants                                                                    |     |   |                           79,307 |     |   |   2,095,772 |     |   |                               — |     |   |           — |
| Convertible Notes                                                           |     |   |                        1,480,502 |     |   |           — |     |   |                               — |     |   |           — |
| Weighted-average shares outstanding for diluted net income (loss) per share |     |   |                      189,924,032 |     |   | 177,617,307 |     |   |                     174,800,967 |     |   | 158,559,467 |

The following potentially dilutive securities were excluded from the computation of diluted weighted average common shares outstanding due to their anti-dilutive effect:

|                                                              |     | Three months ended September 30, |     |            |     | Nine Months Ended September 30, |     |            |            |
|                                                              |     |                             2026 |     |       2025 |     |                            2026 |     |       2025 |            |
| Shares to be issued upon conversion of Convertible Notes     |     |                                — |     | 10,971,895 |     |                               — |     |            | 10,971,895 |
| RSUs                                                         |     |                                — |     |          — |     |                       9,245,814 |     | 13,776,105 |            |
| Stock Options                                                |     |                                — |     |          — |     |                       6,925,293 |     |  5,765,600 |            |
| Warrants                                                     |     |                                — |     |          — |     |                         125,999 |     |  2,664,470 |            |
| Total anti-dilutive securities excluded from EPS computation |     |                                — |     | 10,971,895 |     |                      16,297,106 |     | 33,178,070 |            |

#### Note 15. Segment Reporting
The Company is a single operating and reporting segment dedicated to developing and commercializing therapies for people with chronic endocrine and neurological diseases. The Company has identified the Chief Executive Officer as the chief operating decision maker ("CODM").

The CODM regularly reviews consolidated financial information, including net income (loss), to assess the performance of the Company and allocate resources. The CODM also considers budget versus actual results and revenue trends to evaluate expenditures and allocate resources across the organization.

<div align='center'>21</div>

#### XERIS BIOPHARMA HOLDINGS, INC.

### Notes to Condensed Consolidated Financial Statements
<div align='center'>(unaudited)</div>

The condensed consolidated financial statements provide a comprehensive view of the Company’s overall financial condition, including information on segment assets and liabilities reported in the condensed consolidated balance sheets. The significant expense categories are consistent with those presented on the face of the condensed consolidated statements of operations and comprehensive income (loss), and the CODM does not receive or use any other disaggregated or significant expense information for decision making purposes.

<div align='center'>22</div>

## ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
Cautionary statements for forward-looking information

The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our condensed consolidated financial statements and notes to those financial statements appearing elsewhere in this Quarterly Report on Form 10-Q and with the audited financial statements and the notes to those financial statements included in the Annual Report on Form 10-K filed on March 2, 2026 with the U.S. Securities and Exchange Commission ("SEC"). In addition to financial information, the following discussion contains forward-looking statements that reflect our plans, estimates and beliefs. All statements in this document other than statements of historical fact are, or could be, "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "will," "would," "may," "should," "expects," "focus," "goal," "intends," "plans," "anticipates," "believes," "estimates," "predicts," "potential," "continue," and terms of similar meaning are also generally intended to identify forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including without limitation, the regulatory approval of our product candidates, including potential impacts of changes in or disruptions of U.S. governmental agencies, whether from a future U.S. federal government shutdown, reduced resources or shifting policy priorities and the resulting impact on regulatory feedback and timing thereof, changes in legislative, oversight and regulatory priorities following the November 2026 U.S. elections and potential public responses to the elections or their outcomes, new laws and regulations or amendment to existing laws and regulations in the U.S and foreign countries, changes in the macroeconomic conditions, such as possibility of an economic downturn, concerns regarding a potential global recession or general economic uncertainty, inflationary pressures and capital market disruptions, interest rate fluctuations, our ability to market and sell our products and product candidates if approved, increasing geopolitical tensions and military conflicts, such as the ongoing conflicts between Russia and Ukraine, the U.S. and Iran, and in the Middle East, and market volatility, including announced or implemented tariffs, and factors discussed in Item 1A. Risk Factors in our Annual Report on Form 10-K for the year ended December 31, 2025 and in our other subsequent filings with the SEC, including elsewhere in this Quarterly Report on Form 10-Q. Any forward-looking statements contained herein speak only as of the date hereof, and Xeris expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.

### Overview
Xeris Biopharma Holdings, Inc. along with its subsidiaries, is referenced herein as the "Company," "Xeris," "Xeris Biopharma," "we" or "our." Throughout this document, unless otherwise noted, references to Gvoke include Gvoke PFS, Gvoke HypoPen, and Gvoke Kit.

We are an endocrine and rare disease biopharmaceutical company committed to helping people realize better lives through the development and commercialization of innovative medicines for serious diseases with significant unmet medical need. We have three commercially available products in the United States: Recorlev, a cortisol synthesis inhibitor for the treatment of endogenous hypercortisolemia in patients with Cushing's syndrome; Gvoke, a ready-to-use liquid glucagon for the treatment of severe hypoglycemia; and Keveyis, a therapy for primary periodic paralysis ("PPP"). We also have a pipeline of development programs led by XP-8121, a Phase 3-ready, once-weekly subcutaneous ("SC") levothyroxine injection for the treatment of hypothyroidism, as well as multiple early-stage programs that use our proprietary technology platforms, XeriSol and XeriJect, for ourselves and our partners.

#### Commercial Products
Our top priority is maximizing the potential of our three commercial products:

• Recorlev is a cortisol synthesis inhibitor approved for the treatment of endogenous hypercortisolemia in adult patients with Cushing's syndrome for whom surgery is not an option or has not been curative. Endogenous Cushing's syndrome is a rare but serious and potentially fatal endocrine disease caused by chronic elevated cortisol exposure.

• Gvoke is a ready-to-use, liquid-stable glucagon for the treatment of severe hypoglycemia. The product is indicated for use in pediatric and adult patients with diabetes age two years and above and can be administered in two simple steps.

• Keveyis is the first therapy approved in the United States to treat hyperkalemic, hypokalemic, and related variants of PPP. PPP is a rare genetic, neuromuscular disorder that can cause extreme muscle weakness and/or paralysis; some forms are also commonly associated with myotonia or muscle stiffness.

#### Our Pipeline
Our company name, Xeris, is derived from the ancient Greek word xērós meaning 'dry' or 'without water/non-aqueous'. Our proprietary, non-aqueous formulation capabilities are designed to enable the convenient injection of medicines previously uninjectable or poorly injectable when utilizing aqueous approaches. Both XeriSol and XeriJect offer the opportunity to create ready-to-use, room-temperature stable, highly concentrated, injectable formulations of both small and large molecules.

• XP-8121: We are in the process of developing the first and only, once-weekly, subcutaneous injection of levothyroxine for the treatment of hypothyroidism. We are working with the United States Food and Drug Administration ("FDA") and plan to initiate a Phase 3 clinical trial of our XP-8121 product candidate.

<div align='center'>23</div>

• Partnerships: We are pursuing formulation and development partnerships to apply our XeriSol and XeriJect formulation technologies to enhance the drug delivery and clinical profile of other companies’ proprietary drugs and biologics. We are currently collaborating with several major pharmaceutical companies on the development of formulations of their proprietary therapeutics.

#### Our Strategy
Our strategy is to continue to build a profitable biopharmaceutical company focused on developing and commercializing therapies for people with chronic endocrine and neurological diseases. Xeris is uniquely positioned to execute on this strategy through the continued growth of our three commercial products, which enables us to invest in and develop therapies for unmet medical needs. We believe this will generate value to all of our stakeholders.

#### Patent Rights
As of October 30, 2026, we owned 197 patents issued globally, including composition of matter patents covering our ready-to-use glucagon formulation that expire in 2036. Included in the total patents, we have 70 granted patents globally related to our platform technologies and nine patents granted in the United States and listed in the FDA Orange Book covering proprietary formulations of levoketoconazole (the active pharmaceutical ingredient in Recorlev) and the uses of such formulations in treating certain endocrine-related diseases and syndromes. The latter includes United States Patent Nos. 11,020,393, 11,278,547, 11,903,940, and 12,377,096, which were granted on June 1, 2021, March 22, 2022, February 20, 2024, and August 5, 2025, respectively, and which provide patent protection through 2040 for the use of Recorlev in the treatment of certain patients with persistent or recurrent Cushing's syndrome. In addition, in October 2026, the United States Patent and Trademark Office granted U.S. Patent No. 12,758,502, which relates to Keveyis and which we expect to provide patent protection through at least 2039.

#### Financing
We have funded our operations to date primarily with proceeds from the sale of our preferred and common stock and debt financing.

For the nine months ended September 30, 2026 and 2025, we reported net losses of $17.6 million and $10.5 million, respectively. Our accumulated deficit was $688.9 million. In the near term, we may incur net losses as we, among other things:

| < |     | continue our selling and marketing efforts related to our commercial products;                                                                |
| < |     | continue our research and development efforts;                                                                                                |
| < |     | continue to operate as a public company; and                                                                                                  |
| < |     | continue to fund our operations with an increased cost of borrowing due to a high interest rate environment and tighter lending requirements. |

We may continue to seek public equity and debt financing to meet our capital requirements. There can be no assurance that such funding may be available to us on acceptable terms, or at all, or that we will be able to commercialize our product candidates, if approved. In addition, we may not be profitable even if we commercialize any of our product candidates.

### Components of our Results of Operations
The following discussion sets forth certain components of the statement of operations of Xeris for the three and nine months ended September 30, 2026 and 2025 as well as factors that impact those items.

#### Product revenue, net
Product revenue, net, represents gross product sales less estimated allowances for patient copay assistance programs, prompt payment discounts, payor rebates, chargebacks, service fees, and product returns, all of which are recorded at the time of sale to the pharmaceutical wholesaler or other customer. We apply significant judgment and estimates in determining some of these allowances. If actual results differ from our estimates, we make adjustments to these allowances in the period in which the actual results or updates to estimates become known.

#### Royalty, contract and other revenue
Royalty and contract revenue is recognized as earned in accordance with contract terms when it can be reasonably estimated and collectability is reasonably assured. Revenue generated from various collaboration and technology partnerships is included in this line item.

#### Cost of goods sold
Cost of goods sold primarily includes product costs, which include all costs directly related to the purchase of raw materials, charges from our contract manufacturing organizations, and manufacturing overhead costs, as well as shipping and distribution charges. Cost of goods sold also includes losses from excess, slow-moving or obsolete inventory and inventory purchase commitments, if any.

<div align='center'>24</div>

#### Research and development expenses
Research and development expenses consist of expenses incurred in connection with the discovery and development of our products and product candidates. We recognize research and development expenses as incurred. Expenses that are paid in advance of performance are capitalized until services are provided or goods are delivered. We track external research and development costs by project, however, personnel related expenses related to research and development are not allocated by project. Research and development expenses primarily include:

| < |     | the cost of acquiring and manufacturing nonclinical study and clinical trial materials and manufacturing costs related to commercial production and scale-up until a product is approved and initially available for commercial sale; |
| < |     | expenses incurred under agreements with contract research organizations ("CROs") as well as investigative sites and consultants that conduct our nonclinical studies and clinical trials;                                             |
| < |     | personnel-related expenses, which include salaries, benefits and stock-based compensation;                                                                                                                                            |
| < |     | laboratory materials and supplies used to support our research activities;                                                                                                                                                            |
| < |     | outsourced product development services;                                                                                                                                                                                              |
| < |     | expenses relating to regulatory activities, including filing fees paid to regulatory agencies; and                                                                                                                                    |
| < |     | allocated expenses for facility-related costs.                                                                                                                                                                                        |

Research and development activities are central to our business model. We expect to continue to incur significant research and development expenses as we advance our pipeline candidates and in particular plan and conduct clinical trials, prepare regulatory filings for our product candidates, and utilize internal resources to support these efforts.

Our research and development expenses may vary significantly over time due to uncertainties relating to the timing and results of our clinical trials, feedback received from interactions with the FDA and the timing of regulatory approvals.

#### Selling, general and administrative expenses
Selling, general and administrative expenses consist primarily of compensation and related personnel costs, marketing and selling expenses, professional fees and facility costs not otherwise included in research and development expenses.

#### Amortization of intangible assets
Amortization of intangible assets relates to the amortization of our products: Recorlev and Keveyis. These two intangible assets are being amortized over a five-year and fourteen-year period, respectively, using the straight-line method.

#### Other income (expense)
Other income (expense) consists primarily of interest expense related to our loan and convertible debt, interest income earned on deposits and investments.

<div align='center'>25</div>

### Results of Operations
The following table summarizes our results of operations for the three and nine months ended September 30, 2026 and 2025 (in thousands):

|                                                                 |     |   | Three Months Ended September 30, |     |   |        |     |   | Change |     |         |     |   | Nine Months Ended September 30, |     |   |         |     | Change |     |   |         |     |        |
|:----------------------------------------------------------------|:----|:--|---------------------------------:|:----|:--|-------:|:----|:--|-------:|:----|--------:|:----|:--|--------------------------------:|:----|:--|--------:|:----|:-------|:----|:--|--------:|:----|-------:|
|                                                                 |     |   |                             2026 |     |   |   2025 |     |   |      $ |     |       % |     |   |                            2026 |     |   |    2025 |     |        |     |   |       $ |     |      % |
| Product revenue, net:                                           |     |   |                                  |     |   |        |     |   |        |     |         |     |   |                                 |     |   |         |     |        |     |   |         |     |        |
| Recorlev                                                        |     | $ |                           71,540 |     | $ | 36,975 |     | $ | 34,565 |     |    93.5 |     |   |                         178,088 |     | $ |  93,949 |     |        |     |   |  84,139 |     |   89.6 |
| Gvoke                                                           |     |   |                           21,706 |     |   | 25,151 |     |   | -3,445 |     |   -13.7 |     |   |                          65,055 |     |   |  69,463 |     |        |     |   |  -4,408 |     |   -6.3 |
| Keveyis                                                         |     |   |                           13,021 |     |   | 11,937 |     |   |  1,084 |     |     9.1 |     |   |                          36,582 |     |   |  34,849 |     |        |     |   |   1,733 |     |    5.0 |
| Other product revenue                                           |     |   |                                — |     |   |      — |     |   |      — |     |       — |     |   |                               — |     |   |   1,312 |     |        |     |   |  -1,312 |     | -100.0 |
| Product revenue, net                                            |     |   |                          106,267 |     |   | 74,063 |     |   | 32,204 |     |    43.5 |     |   |                         279,725 |     |   | 199,573 |     |        |     |   |  80,152 |     |   40.2 |
| Royalty, contract and other revenue                             |     |   |                              958 |     |   |    317 |     |   |    641 |     |   202.2 |     |   |                           2,727 |     |   |   6,465 |     |        |     |   |  -3,738 |     |  -57.8 |
| Total revenue                                                   |     |   |                          107,225 |     |   | 74,380 |     |   | 32,845 |     |    44.2 |     |   |                         282,452 |     |   | 206,038 |     |        |     |   |  76,414 |     |   37.1 |
| Cost and expenses:                                              |     |   |                                  |     |   |        |     |   |        |     |         |     |   |                                 |     |   |         |     |        |     |   |         |     |        |
| Cost of goods sold, excluding amortization of intangible assets |     |   |                           12,429 |     |   | 10,996 |     |   |  1,433 |     |    13.0 |     |   |                          35,515 |     |   |  31,622 |     |        |     |   |   3,893 |     |   12.3 |
| Research and development                                        |     |   |                           11,058 |     |   |  7,483 |     |   |  3,575 |     |    47.8 |     |   |                          30,510 |     |   |  23,291 |     |        |     |   |   7,219 |     |   31.0 |
| Selling, general and administrative                             |     |   |                           64,108 |     |   | 46,459 |     |   | 17,649 |     |    38.0 |     |   |                         178,287 |     |   | 134,870 |     |        |     |   |  43,417 |     |   32.2 |
| Amortization of intangible assets                               |     |   |                            2,711 |     |   |  2,711 |     |   |      — |     |       — |     |   |                           8,132 |     |   |   8,132 |     |        |     |   |       — |     |      — |
| Total cost and expenses                                         |     |   |                           90,306 |     |   | 67,649 |     |   | 22,657 |     |    33.5 |     |   |                         252,444 |     |   | 197,915 |     |        |     |   |  54,529 |     |   27.6 |
| Income from operations                                          |     |   |                           16,919 |     |   |  6,731 |     |   | 10,188 |     |   151.4 |     |   |                          30,008 |     |   |   8,123 |     |        |     |   |  21,885 |     |  269.4 |
| Other income (expense):                                         |     |   |                                  |     |   |        |     |   |        |     |         |     |   |                                 |     |   |         |     |        |     |   |         |     |        |
| Interest and other income                                       |     |   |                              827 |     |   |  1,158 |     |   |   -331 |     |   -28.6 |     |   |                           3,484 |     |   |   3,281 |     |        |     |   |     203 |     |    6.2 |
| Loss on debt extinguishment                                     |     |   |                                — |     |   |      — |     |   |      — |     |       — |     |   |                         -30,782 |     |   |       — |     |        |     |   | -30,782 |     |      — |
| Interest expense                                                |     |   |                           -6,456 |     |   | -7,268 |     |   |    812 |     |    11.2 |     |   |                         -20,287 |     |   | -21,931 |     |        |     |   |   1,644 |     |    7.5 |
| Total other expense                                             |     |   |                           -5,629 |     |   | -6,110 |     |   |    481 |     |    -7.9 |     |   |                         -47,585 |     |   | -18,650 |     |        |     |   | -28,935 |     |  155.1 |
| Net income (loss) before income taxes                           |     |   |                           11,290 |     |   |    621 |     |   | 10,669 |     | 1,718.0 |     |   |                         -17,577 |     |   | -10,527 |     |        |     |   |  -7,050 |     |  -67.0 |
| Income tax benefit (expense)                                    |     |   |                                — |     |   |      — |     |   |      — |     |       — |     |   |                               — |     |   |       — |     |        |     |   |       — |     |      — |
| Net income (loss)                                               |     | $ |                           11,290 |     | $ |    621 |     | $ | 10,669 |     |  1718.0 |     | $ |                         -17,577 |     | $ | -10,527 |     |        |     | $ |  -7,050 |     |  -67.0 |

#### Product revenue, net
Recorlev

Net revenue increased by $34.6 million or 93.5% for the three months ended September 30, 2026 compared to the three months ended September 30, 2025. The increase was due to higher volume ($27.5 million or 74.2%), primarily driven by increased patient demand, and favorable net pricing ($7.1 million or 19.3%).

Net revenue increased by $84.1 million or 89.6% for the nine months ended September 30, 2026 compared to the nine months ended September 30, 2025. The increase was due to higher volume ($70.0 million or 74.5%), primarily driven by increased patient demand, and favorable net pricing ($14.1 million or 15.1%).

Gvoke

Net revenue decreased by $3.4 million or 13.7% for the three months ended September 30, 2026 compared to the three months ended September 30, 2025. The decrease was due to unfavorable net pricing ($4.2 million or 16.8%), partially offset by higher volume ($0.8 million or 3.1%).

Net revenue decreased by $4.4 million or 6.3% for the nine months ended September 30, 2026 compared to the nine months ended September 30, 2025. The decrease was due to unfavorable net pricing ($3.3 million or 4.7%) and lower volume ($1.1 million or 1.6%).

<div align='center'>26</div>

Keveyis

Net revenue increased by $1.1 million or 9.1% for the three months ended September 30, 2026 compared to the three months ended September 30, 2025. The increase was due to favorable net pricing ($1.2 million or 9.6%), partially offset by lower volume ($0.1 million or 0.5%).

Net revenue increased by $1.7 million or 5.0% for the nine months ended September 30, 2026 compared to the nine months ended September 30, 2025. The increase was due to favorable net pricing ($2.4 million or 7.1%), partially offset by lower volume ($0.7 million or 2.1%).

#### Royalty, contract and other revenue
Royalty, contract and other revenue increased $0.6 million or 202.2% for the three months ended September 30, 2026 compared to the three months ended September 30, 2025. The increase primarily reflects revenue from partnership agreements in 2026.

Royalty, contract and other revenue decreased $3.7 million or 57.8% for the nine months ended September 30, 2026 compared to the nine months ended September 30, 2025. The decrease primarily reflects the recognition of a milestone from a partnership agreement in 2025.

#### Cost of goods sold
Cost of goods sold increased by $1.4 million or 13.0% for the three months ended September 30, 2026 compared to the same period ended September 30, 2025. Cost of goods sold increased by $3.9 million or 12.3% for the nine months ended September 30, 2026 compared to the same period ended September 30, 2025.

Cost of goods sold as a percent of total product revenue improved by 3.1%, to 11.7% for the three months ended September 30, 2026 compared to 14.8% for the same period ended September 30, 2025, primarily due to favorable product mix dynamics ($1.8 million or 2.5%) and lower write-downs of expired and excess inventory ($0.6 million or 0.6%).

Cost of goods sold as a percent of total product revenue improved by 3.1%, to 12.7% for the nine months ended September 30, 2026 compared to 15.8% for the same period ended September 30, 2025, primarily due to favorable product mix dynamics ($8.3 million or 4.1%), offset by higher write-downs of expired and excess inventory ($2.8 million or 1.0%).

#### Research and development expenses
Research and development expenses increased by $3.6 million or 47.8% for the three months ended September 30, 2026 compared to the same period ended September 30, 2025. This increase was primarily due to higher pipeline expense ($2.4 million) and higher personnel related expense ($1.1 million) to support XP-8121.

Research and development expenses increased by $7.2 million or 31.0% for the nine months ended September 30, 2026 compared to the same period ended September 30, 2025. This increase was primarily due to higher pipeline expense ($3.8 million) and higher personnel related expense ($3.7 million) to support XP-8121, partially offset by lower technology development expense ($0.6 million).

The following table summarizes our research and development expenses by type for the nine months ended September 30, 2026 and 2025 (in thousands):

|                                         |     |   | Three Months Ended September 30, |     |   |       |     |   | Change |     |       |     |   | Nine Months Ended September 30, |        |   |        |     | Change |     |   |       |       |     |       |
|:----------------------------------------|:----|:--|---------------------------------:|:----|:--|------:|:----|:--|-------:|:----|------:|:----|:--|--------------------------------:|-------:|:--|-------:|:----|:-------|:----|:--|------:|------:|:----|------:|
|                                         |     |   |                             2026 |     |   |  2025 |     |   |      $ |     |     % |     |   |                            2026 |        |   |   2025 |     |        |     |   |     $ |       |     |     % |
| Project specific expenses:              |     |   |                                  |     |   |       |     |   |        |     |       |     |   |                                 |        |   |        |     |        |     |   |       |       |     |       |
| Pipeline                                |     | $ |                            4,455 |     | $ | 2,015 |     | $ |  2,440 |     | 121.1 |     | $ |                          10,849 |        | $ |  7,046 |     |        |     | $ | 3,803 |       |     |  54.0 |
| Technology development(1)               |     |   |                               16 |     |   |    29 |     |   |    -13 |     | -44.8 |     |   |                                 |    205 |   |    844 |     |        |     |   |  -639 |       |     | -75.7 |
| Personnel related expenses              |     |   |                            5,904 |     |   | 4,826 |     |   |  1,078 |     |  22.3 |     |   |                                 | 17,124 |   | 13,377 |     |        |     |   |       | 3,747 |     |  28.0 |
| Lab supplies and equipment depreciation |     |   |                              459 |     |   |   368 |     |   |     91 |     |  24.7 |     |   |                                 |  1,422 |   |  1,144 |     |        |     |   |       |   278 |     |  24.3 |
| Other                                   |     |   |                              224 |     |   |   245 |     |   |    -21 |     |  -8.6 |     |   |                                 |    910 |   |    880 |     |        |     |   |       |    30 |     |   3.4 |
| Total                                   |     | $ |                           11,058 |     | $ | 7,483 |     | $ |  3,575 |     |  47.8 |     | $ |                          30,510 |        | $ | 23,291 |     |        |     | $ | 7,219 |       |     |  31.0 |

(1) Technology development represents any investment in our proprietary technology platforms, XeriSol and XeriJect.

#### Selling, general and administrative expenses
Selling, general and administrative expenses increased $17.6 million or 38.0% for the three months ended September 30, 2026 compared to the same period ended September 30, 2025. This increase was primarily due to higher personnel related expense ($12.0 million) to support the commercial enterprise, including the Recorlev expansion.

<div align='center'>27</div>

Selling, general and administrative expenses increased $43.4 million or 32.2% for the nine months ended September 30, 2026 compared to the same period ended September 30, 2025. This increase was primarily due to higher personnel related expense ($34.7 million) to support the commercial enterprise, including the Recorlev expansion.

#### Amortization of intangible assets
For the three and nine months ended September 30, 2026 and September 30, 2025, amortization of intangible assets were both $2.7 million and $8.1 million, respectively.

#### Other income (expense)
For the three months ended September 30, 2026, interest expense decreased $0.8 million or 11.2% compared to the same period ended September 30, 2025. This decrease was primarily due to a reduction in the interest rate and settlement of the 2028 Convertible Notes disclosed in "Note 8 - Debt."

For the nine months ended September 30, 2026, interest expense decreased $1.6 million or 7.5% compared to the same period ended September 30, 2025. This decrease was primarily due to a reduction in the interest rate and settlement of the 2028 Convertible Notes disclosed in "Note 8 - Debt."

During the nine months ended September 30, 2026, the Company executed an exchange agreement with certain holders of the 2028 Convertible Notes to enable settlement of the outstanding principal amount in cash. Execution of this exchange agreement resulted in recognition of an extinguishment loss of $30.8 million.

### Liquidity and Capital Resources
Our primary uses of cash are to fund costs related to the manufacturing, marketing and selling of products, the research and development of our product candidates, general and administrative expenses and working capital requirements. Historically, we have funded our operations primarily through private placements of convertible preferred stock, public equity offerings of common stock, and the issuance of debt.

Financing Transactions

In May 2022, we entered into an Open Market Sale Agreement with Jefferies LLC, as sales agent, dated May 11, 2022 ("Sales Agreement") for the offering, issuance and sale of up to a maximum aggregate offering price of $75.0 million of our common stock. The Sales Agreement will terminate upon the earlier of (i) the sale of all shares of common stock subject to the Sales Agreement and (ii) the termination of the Sales Agreement as permitted therein. Either party may terminate the Sales Agreement at any time upon ten days’ prior notice. To date, we have not sold any shares pursuant to the Sales Agreement.

In September 2023, we completed the exchange of $32.0 million in aggregate principal amount of our 5.00% Convertible Senior Notes due 2025 ("2025 Convertible Notes") for $33.6 million in aggregate principal amount of our 8.00% Convertible Senior Notes due 2028 ("2028 Convertible Notes").

In March 2024, we entered into an Amended and Restated Credit Agreement and Guaranty (the "Amended and Restated Credit Agreement") with the lenders from time to time parties thereto (the "Lenders") and Hayfin Services LLP, as administrative agent for the New Lenders, pursuant to which we and our subsidiaries granted a first priority security interest on substantially all of our assets, including intellectual property, subject to certain exceptions. The Amended and Restated Credit Agreement provides for the Lenders to extend $200.0 million in term loans to the Company on the closing date and up to an additional $15.2 million in additional term loans, which additional term loans are available only to redeem the Company's then outstanding 2025 Convertible Notes.

In March and April of 2025, holders of the 2025 Convertible Senior Notes converted the outstanding $15.2 million in aggregate principal amount of the notes into 4,978,151 shares of the Company's common stock. Following the completion of the exchange transactions and the conversion, no 2025 Convertible Notes remain outstanding.

In June 2026, we executed an exchange agreement with certain holders of the 2028 Convertible Notes to enable settlement of the outstanding principal amount in cash. Execution of this exchange agreement resulted in recognition of an extinguishment loss of $30.8 million, which represents the difference between the amortized cost of the 2028 Convertible Notes immediately prior to the exchange and their fair value of $53.7 million. This exchange resulted in a loss on extinguishment of debt of $30.8 million, recognized in other income (expense) on the condensed consolidated statements of operations and comprehensive income (loss).

In July 2026, we completed the privately negotiated exchange transactions with certain holders of our 2028 Convertible Notes ("collectively, the "Exchanging Noteholders"), pursuant to which the Exchanging Noteholders exchanged approximately $23.1 million in aggregate principal amount of their 2028 Convertible Notes for an aggregate of approximately 5.0 million shares of our common stock and approximately $23.1 million in cash and, separately, a holder of approximately $10.5 million in principal amount of the 2028 Convertible Notes elected to convert its 2028 Convertible Notes into approximately 3.6 million shares of our common stock. Following the completion of the exchange transactions and the conversion, no 2028 Convertible Notes remain outstanding.

Capital Resources and Funding Requirements

We have an accumulated deficit of $688.9 million at September 30, 2026. Based on our current operating plans and existing working capital at September 30, 2026, we believe that our cash resources are sufficient to sustain operations and capital expenditure

<div align='center'>28</div>

requirements for at least the next twelve months. We may incur substantial additional expenditures in the near term to support the marketing and selling of Recorlev, Gvoke and Keveyis, as well as our planned research and development activities related to XP-8121. We may incur net losses for at least the next twelve months. Our ability to fund the marketing and selling of Recorlev, Gvoke and Keveyis, as well as our product development and clinical operations, including completion of future clinical trials, will depend on the amount and timing of cash received from product revenue and potential future financings. Our future capital requirements will depend on many factors, including, but not limited to:

| < |     | our degree of success in commercializing Recorlev, Gvoke and Keveyis;                                                                             |
| < |     | the costs of commercialization activities, including product marketing, sales and distribution;                                                   |
| < |     | the costs, timing and outcomes of clinical trials and regulatory reviews associated with our product candidates;                                  |
| < |     | the effect on our product development activities of actions taken by the FDA or other regulatory authorities;                                     |
| < |     | the number and types of future products we develop and commercialize;                                                                             |
| < |     | the emergence of competing technologies and products and other adverse market developments; and                                                   |
| < |     | the costs of preparing, filing and prosecuting patent applications and maintaining, enforcing and defending intellectual property-related claims. |

As we continue the marketing and selling of Recorlev, Gvoke and Keveyis, we may not generate a sufficient amount of product revenue to fund our cash requirements. Accordingly, we may need to obtain additional financing in the future which may include public or private debt and/or equity financings. As detailed in the section titled "Financing" included in "Item 2 - Management's Discussion and Analysis of Financial Condition and Results of Operations" of Part I of this Quarterly Report, there can be no assurance that such funding may be available to us on acceptable terms, or at all, or that we will be able to successfully market and sell Recorlev, Gvoke and Keveyis.

| Cash Flows                                          
 (in thousands)                                      |     |   | Nine Months Ended September 30, 
                            2026 |     |   |   2025 |
|:----------------------------------------------------|:----|:--|--------------------------------:|:----|:--|-------:|
| Net cash provided by operating activities           |     | $ |                          53,603 |     | $ |  8,583 |
| Net cash used in investing activities               |     | $ |                            -693 |     | $ |   -363 |
| Net cash (used in) provided by financing activities |     | $ |                         -32,870 |     | $ | 11,655 |

Operating Activities

Net cash provided by operating activities was $53.6 million for the nine months ended September 30, 2026, compared to $8.6 million provided by operating activities for the nine months ended September 30, 2025. The increase in net cash provided by operating activities was primarily driven by higher product sales. For a discussion regarding product revenue, net and increases in spending, refer to "Results of Operations" included in this "Item 2 - Management's Discussion and Analysis of Financial Condition and Results of Operations" of Part I of this Quarterly Report on Form 10-Q.

Investing Activities

Net cash used in investing activities was $0.7 million for the nine months ended September 30, 2026, compared to $0.4 million used in investing activities for the nine months ended September 30, 2025. The increase in cash used by investing activities for the nine months ended September 30, 2026 was due to higher capital expenditures.

Financing Activities

Net cash used in financing activities was $32.9 million for the nine months ended September 30, 2026, compared to $11.7 million provided by financing activities for the nine months ended September 30, 2025. The net cash used in financing activities for the nine months ended September 30, 2026 was primarily driven by cash paid to settle the 2028 Convertible Notes of $23.1 million and repurchases of common stock withheld for taxes of $18.0 million, offset by proceeds from the exercise of stock options of $2.0 million and proceeds from the issuance of shares of common stock upon settlement of warrants of $7.9 million. The net cash provided by financing activities for the nine months ended September 30, 2025 was primarily driven by proceeds from the exercise of stock options of $11.0 million and proceeds from the issuance of shares of common stock upon settlement of warrants of $9.2 million, offset by repurchases of common stock withheld for taxes of $9.3 million.

### CRITICAL ACCOUNTING POLICIES AND USE OF ESTIMATES AND ASSUMPTIONS
Our Annual Report on Form 10-K for the year ended December 31, 2025 describes the critical accounting policies for which management uses significant judgments and estimates in the preparation of our condensed consolidated financial statements. There have been no significant changes to our critical accounting policies since December 31, 2025.

<div align='center'>29</div>

### NEW ACCOUNTING STANDARDS
Refer to Note 2 — Basis of presentation and summary of significant accounting policies and estimates , for a description of recent accounting pronouncements applicable to our financial statements.

## ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
We are subject to certain market risks arising from transactions in the normal course of business, principally risk associated with interest rate and foreign currency exchange rate fluctuations.

#### Interest Rate Risk
Cash, Cash Equivalents Restricted Cash and Investments —We are exposed to the risk of interest rate fluctuations on the interest income earned on our cash, cash equivalents, restricted cash and investments. A hypothetical one-percentage point increase or decrease in interest rates applicable to our cash, cash equivalents, restricted cash and investments outstanding at September 30, 2026 would increase or decrease interest income by approximately $1.4 million on an annual basis.

Long-term Debt —Our interest rate risk relates primarily to the United States dollar SOFR-indexed borrowings. Based on our outstanding borrowings pursuant to the Amended and Restated Credit Agreement, interest is incurred at a floating per annum rate in an amount equal to the sum of (i) 6.95% (or 5.95% if the replacement rate is in effect) plus (ii) the greater of (x) the forward-looking term rate based on SOFR for a three month tenor (or the replacement rate, if applicable), and (y) 2.00% per annum. The remaining balance of unamortized debt issuance costs have been reflected as a direct reduction to the loan balance.

#### Foreign Currency Exchange Risk
We contract with organizations outside the United States at times. We may be subject to fluctuations in foreign currency exchange rates in connection with certain of these agreements. Transactions denominated in currencies other than the functional currency are recorded based on exchange rates at the time such transactions arise. Net foreign currency gains and losses did not have a material effect on our results of operations for the nine months ended September 30, 2026.

## ITEM 4. CONTROLS AND PROCEDURES

### Evaluation of Disclosure Controls and Procedures
Our management, with the participation of our chief executive officer (principal executive officer) and chief financial officer (principal financial officer), evaluated the effectiveness of our disclosure controls and procedures, as such term is defined under Rules 13a-15(e) and 15d-15(e) promulgated under the Securities Exchange Act of 1934, as amended ("Exchange Act"). Based on such evaluation, our chief executive officer and chief financial officer have concluded that the disclosure controls and procedures were effective as of September 30, 2026 to ensure that information required to be disclosed by the Company in the reports it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time period specified in the SEC rules and forms, and to ensure that information required to be disclosed by the Company in the reports it files or submits under the Exchange Act is accumulated and communicated to the Company's management, including its chief executive and chief financial officers, as appropriate, to allow timely decisions regarding required disclosure.

### Changes in Internal Control Over Financial Reporting
There were no changes in our internal control over financial reporting identified in connection with the evaluation required by Rules 13a-15(d) and 15d-15(d) of the Exchange Act that occurred during the three months ended September 30, 2026 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

<div align='center'>30</div>

#### PART II. OTHER INFORMATION

## ITEM 1. LEGAL PROCEEDINGS
On February 26, 2026, March 20, 2026, June 4, 2026, and July 13, 2026, the Company’s wholly owned subsidiaries, Xeris Pharmaceuticals, Inc. and Strongbridge Dublin Limited, filed patent infringement lawsuits under the Hatch-Waxman Act in the United States District Court for the District of New Jersey against defendants (i) Torrent Pharmaceuticals Limited (along with its affiliate, “Torrent”) and Somerset Therapeutics, LLC (along with its affiliates, “Somerset”), (ii) Sandoz Inc. (“Sandoz”) and Zydus Lifesciences Global FZE (along with its affiliates, “Zydus”), and (iii) Novitium Pharma, LLC (along with its affiliate, “Novitium”) in two separate actions, respectively (each, an “ANDA Filer”). These lawsuits were filed following receipt of a Paragraph IV certification notice letter (each, a “Notice Letter”) from each of Torrent, Somerset, Sandoz, Zydus, and Novitium regarding the filing of its respective Abbreviated New Drug Application (“ANDA”) with the U.S. Food and Drug Administration (“FDA”) seeking approval to manufacture, use, or sell a generic version of Recorlev®. The Notice Letters stated that each ANDA Filer’s ANDAs contained Paragraph IV certifications alleging that four of the Company’s Orange Book-listed patents covering Recorlev® (U.S. Patent Nos. 11,020,393, 11,278,547, 11,903,940 and 12,377,096) (collectively, the “Orange Book Patents”), which are scheduled to expire in March 2040, are invalid, unenforceable and/or will not be infringed by each ANDA Filer’s manufacture, use, or sale of the generic product described in its respective ANDA submission.

Collectively, the complaints allege that, by filing ANDAs for their respective generic products, each of Torrent, Somerset, Sandoz, Zydus, and Novitium has infringed the Orange Book Patents for Recorlev®. The complaints seek an order preventing the FDA from granting final approval of the respective ANDAs before the expiration of the Orange Book Patents and a permanent injunction to prevent each of the defendants from commercializing a generic version of Recorlev®, until the expiration of the Orange Book Patents, including any applicable extensions and additional periods of exclusivity. On June 8, 2026, the United States District Court for the District of New Jersey entered an order consolidating for all pretrial purposes the actions filed on February 26, 2026 against Somerset and Torrent and the action filed on March 20, 2026 against Sandoz and Zydus (“Consolidated Action”). On July 20, 2026, the United States District Court for the District of New Jersey entered an order consolidating for all pretrial purposes the actions against Novitium filed on June 4, 2026 and July 13, 2026 into the Consolidated Action. A bench trial has been tentatively scheduled for November 2028. The filing of each lawsuit within 45 days of receipt of each of the respective Notice Letters triggered an automatic stay of the FDA’s approval of each of the respective ANDAs in accordance with the Hatch-Waxman Act until up to June 30, 2029, in the absence of a decision from the court finding all asserted claims invalid or not infringed before that date.

The Company may receive additional Notice Letters in the future from ANDA filers seeking approval of a generic version of Recorlev and may file additional ANDA lawsuits in the future.

On October 13, 2026, the Company, through its wholly owned subsidiary, Xeris Pharmaceuticals, Inc., filed patent infringement lawsuits in the United States District Court for the District of New Jersey against defendants (i) Torrent Pharma Inc., Torrent Pharmaceuticals Limited, Cycle Pharmaceuticals Limited, Lemed Pharmacy III, LLC, and Lemed Specialty Pharmacy Arizona, LLC; and (ii) Rising Pharma Holdings, Inc. and Rising Pharma Specialties Pvt. Ltd. in two separate actions. These lawsuits were filed following the grant of U.S. Patent No. 12,758,502 (the “’502 patent”) related to the Company’s KEVEYIS® (dichlorphenamide) product.

The complaints allege that each of the defendants will infringe the ’502 patent by making, using, selling, offering for sale, and/or importing their generic dichlorphenamide products. The Company is seeking a judgment of infringement, injunctive relief prohibiting further infringement, monetary damages adequate to compensate for the infringement, enhanced damages where permitted by law, attorneys’ fees, costs, and such other relief as the court deems appropriate.

We are also involved in various other legal proceedings arising in the normal course of business. Although the outcomes of these other legal proceedings are inherently difficult to predict, we do not expect the resolution of these other legal proceedings to have a material adverse effect on our financial position, results of operations, or cash flows.

<div align='center'>31</div>

## ITEM 1A. RISK FACTORS
In addition to the information set forth in this report, you should carefully consider the risks discussed under the heading "Risk Factors" in our Annual Report on Form 10-K for the year ended December 31, 2025 and subsequent filings with the SEC, which could have a material adverse effect on our business or consolidated financial statements, results of operations, and cash flows. Additional risks not currently known, or risks that are currently believed to be not material, may also impair business operations. There have been no material changes to our risk factors since the filing of our Annual Report on Form 10-K for the year ended December 31, 2025.

## ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS
(a) Recent Sales of Unregistered Securities

None.

(b) Use of Proceeds from Initial Public Offering

Not applicable.

(c) Issuer Purchases of Equity Securities

None.

## ITEM 3. DEFAULTS UPON SENIOR SECURITIES
Not applicable.

## ITEM 4. MINE SAFETY DISCLOSURES
Not applicable.

## ITEM 5. OTHER INFORMATION
Rule 10b5-1 Trading Plan

On August 13, 2026, Marla Persky, the Lead Independent Director of the Company's board of directors, adopteda Rule 10b5-1 trading arrangement providing for the sale from time to time of an aggregate of up to 7,500shares of the Company's common stock. The trading arrangement is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). The duration of the trading arrangement is until June 30, 2027, subject to the earlier termination as provided in the plan.

Except as described above, during the quarter ended September 30, 2026, none of the Company's other directors or officers (as defined in Rule 16a-1(f)) adopted, materially modified, or terminatedany contract, instruction, or written plan for the purchase or sale of Company securities under a “Rule 10b5-1 trading arrangement” or any “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(c) of Regulation S-K of the Exchange Act.

<div align='center'>32</div>

## ITEM 6. EXHIBITS
The exhibits filed as part of this Quarterly Report on Form 10-Q are set forth on the Index to Exhibits, which is incorporated herein by reference.

| Exhibit No. |     | Description                                                                                                                                                                                                                                                |
| 3.1         |     | Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K12B (File No. 001-40880) filed with the Securities and Exchange Commission on October 5, 2021) |
| 3.2         |     | Amended and Restated By-laws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K12B (File No. 001-40880) filed with the Securities and Exchange Commission on October 5, 2021)                      |
| 31.1*       |     | Certification of Principal Executive Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as amended                                                                                                                                 |
| 31.2*       |     | Certification of Principal Financial Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as amended                                                                                                                                 |
| 32.1*+      |     | Certifications of Principal Executive and Financial Officers pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                                                                      |
| 101.INS*    |     | XBRL Instance Document                                                                                                                                                                                                                                     |
| 101.SCH*    |     | Inline XBRL Taxonomy Extension Schema Document                                                                                                                                                                                                             |
| 101.CAL*    |     | Inline XBRL Taxonomy Extension Calculation Linkbase Document                                                                                                                                                                                               |
| 101.DEF*    |     | Inline XBRL Taxonomy Extension Definition Linkbase Document                                                                                                                                                                                                |
| 101.LAB*    |     | Inline XBRL Taxonomy Extension Label Linkbase Document                                                                                                                                                                                                     |
| 101.PRE*    |     | Inline XBRL Taxonomy Extension Presentation Linkbase Document                                                                                                                                                                                              |
| 104*        |     | Cover Page Interactive Data File (embedded within the Inline XBRL document)                                                                                                                                                                                |

* Filed herewith. All other exhibits listed have previously been filed with the SEC and are incorporated herein by reference.

+ The certifications furnished in Exhibit 32.1 hereto are deemed to accompany this report and will not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended. Such certifications will not be deemed to be incorporated by reference into any filings under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent that the Registrant specifically incorporates it by reference.

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### SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

| Date: |     | November 5, 2026 |     | Xeris Biopharma Holdings, Inc. 
 By:                            |     | /s/ John Shannon                                              |
|:------|:----|:-----------------|:----|:-------------------------------|:----|:--------------------------------------------------------------|
|       |     |                  |     |                                |     | John Shannon                                                  |
|       |     |                  |     |                                |     | Chief Executive Officer and Chairman of the Board             |
|       |     |                  |     |                                |     | -Principal Executive Officer                                  |
| Date: |     | November 5, 2026 |     | By:                            |     | /s/ Steven M. Pieper                                          |
|       |     |                  |     |                                |     | Steven M. Pieper                                              |
|       |     |                  |     |                                |     | Chief Financial Officer                                       |
|       |     |                  |     |                                |     | -Principal Financial Officer and Principal Accounting Officer |

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